Levine M et al. Estimating the impact of adopting the revised Uited Kingdom acetaminophen treatment nomogram in the U.S. population. Clin Toxicol. 2017; doi: 10.1080/15563650.2017.1291945
- Acetaminophen poisoning is extremely common. Recently, European guidelines have lowered the treatment threshold, resulting in a significant increase in the number of patients treated, without clear clinical benefit. This retrospective study looked at the potential cost to the health care system if such a policy change was enacted in the United States. Based on extrapolation from patients identified at 8 participating centers, this study estimates an additional 4500 patients would be treated annually, to a cost of $45 million. Although there is significant interest in re-thinking the management of acetaminophen toxicity in the Tox and EM community, before adopting a policy not clearly founded in a clinical concern, the risks and consequences of such a policy should be seriously considered.
- Recommended by: Meghan Spyres