OVERVIEW Sickle cell disease is caused by HbS haemoglobinopathy which produces rigid, distorted and dysfunctional erythrocytes called sickle cells CAUSE Types of sickle cell disease sickle cell anemia (usually homozygous SS genotype) sickle beta thalassemia sickle HbC disease PRECIPITANTS Commonly: infection dehydration hypoxia drugs (e.g. sedatives, local anaesthetics) Patients with sickle cell disease are at … Continue reading Sickle Cell Crisis