Tag COX II Inhibitors
CCC Critical Care compendium 340

COX II Inhibitors

Selective COX-2 inhibitors developed to try and inhibit prostacyclin synthesis by the COX-2 isoenzyme induced at sites of inflammation without affecting the action of the constitutively active COX-1 isoenzyme found in gastic mucosa, platelets & kidney.
CCC Critical Care compendium 340


Celecoxib: COX II inhibitor; blocks access of arachidonic acid to active site at apex of a hydrophobic channel on COX-2