Tag Pralidoxime


Pralidoxime reactivates acetylcholinesterase only if irreversible binding to the OP has not already occurred ("ageing"). The acetylcholinesterase enzyme has two parts to it. In organophosphate poisoning, an organophosphate binds to just one end of the acetylcholinesterase enzyme (the esteric site), blocking its activity.
CCC Critical Care compendium 340

Organophosphate Poisoning

Organophosphate Poisoning: common cause of poisoning in the developing world; covalent bonding with inactivation of acetylcholinesterase; results in cholinergic crisis