Category CCC

The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.

CCC Critical Care compendium 340

Sildenafil

Sildenafil: potent selective phosphodiesterase inhibitor; inhibition of cGMP-specific phosphodiesterase -> pulmonary vasodilator

CCC Critical Care Compendium 680

Prothrombinex-VF

Prothrombinex: human plasma derivative; The 3 factor prothrombin complex concentrate available in Australia

CCC Critical Care compendium 340

Propofol

Propofol: IV hypnotic agent; potentiates the inhibitory transmitters glycine & GABA which enhance spinal inhibition.

CCC Critical Care compendium 340

Sotalol

Sotalol: anti-arrhythmic; low doses = non-selective beta receptor antagonist; high doses = prolongs action potential

CCC Critical Care compendium 340

Statins in the Critically Ill

Statins (HMG CoA reductase inhibitors) are the most widely used drugs for lowering serum cholesterol levels. Statins also have anti-inflammatory, anti-oxidant and immune-modulating effects (ie independent lipid-lowering effects) which may attenuate end-organ dysfunction in a number of syndromes

CCC Critical Care compendium 340

Sugammadex CCC

Sugammadex is used for reversal of the amino steroid neuromuscular blocking drugs rocuronium, vecuronium and pancuronium.

CCC Critical Care compendium 340

Terlipressin

Terlipressin: synthetic vasopressin analogue with relative specificity for the splanchnic circulation where it causes vasoconstriction in these vessels with a reduction in portal pressure.

CCC Critical Care compendium 340

Tirofiban

Tirofiban: anti-platelet agent; glycoprotein IIb/IIIa antagonist -> stops platelet aggregation