Sildenafil
Sildenafil: potent selective phosphodiesterase inhibitor; inhibition of cGMP-specific phosphodiesterase -> pulmonary vasodilator
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Rifampicin
Rifampicin: inhibits DNA-dependent RNA polymerase activity
Prothrombinex-VF
Prothrombinex: human plasma derivative; The 3 factor prothrombin complex concentrate available in Australia
Propofol
Propofol: IV hypnotic agent; potentiates the inhibitory transmitters glycine & GABA which enhance spinal inhibition.
Urinary Catheterisation
Indications Contraindications: Choose the correct catheter Handy Hints: References and Links
Sotalol
Sotalol: anti-arrhythmic; low doses = non-selective beta receptor antagonist; high doses = prolongs action potential
Statins in the Critically Ill
Statins (HMG CoA reductase inhibitors) are the most widely used drugs for lowering serum cholesterol levels. Statins also have anti-inflammatory, anti-oxidant and immune-modulating effects (ie independent lipid-lowering effects) which may attenuate end-organ dysfunction in a number of syndromes
Sugammadex CCC
Sugammadex is used for reversal of the amino steroid neuromuscular blocking drugs rocuronium, vecuronium and pancuronium.
Tenecteplase (TNK-tPA)
Tenecteplase is a tissue plasminogen activator used as a thrombolytic medication in: Acute Ischaemic Strokes, Acute Myocardial Infarction, PE
Terlipressin
Terlipressin: synthetic vasopressin analogue with relative specificity for the splanchnic circulation where it causes vasoconstriction in these vessels with a reduction in portal pressure.
Tirofiban
Tirofiban: anti-platelet agent; glycoprotein IIb/IIIa antagonist -> stops platelet aggregation
Adaptive Support Ventilation
Adaptive support ventilation (ASV) is a positive pressure mode of mechanical ventilation that is closed-loop controlled, and automatically adjusts based on the patient's requirements