APACHE versus SOFA scoring systems
APACHE = Acute Physiology, Age and Chronic Health Evaluation (I-IV); SOFA = Sequential Organ Failure Assessment
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
ICU Scoring Systems
Scoring systems commonly used in ICU: GCS; TISS; APACHE; SAPS; MPM; POSSUM; EuroSCORE; MELD and SOFA
Multiple Organ Dysfunction Syndrome
Multiple Organ Dysfunction Syndrome (MODS) is a hypometabolic, immunodepressed state with clinical and biochemical evidence of decreased functioning of the body's organ systems that develops subsequent to an acute injury or illness.
Antimicrobial Dosing and Kill Characteristics
Dosing is different to non-critically ill patients
Different antimicrobials have different kill characteristics, which can be demonstrated on a concentration vs time graph for antibiotic activity
Paediatric Asthma
See RCH Melbourne Guidelines:
Cognitive Dispositions to Respond
Reviewed and revised 8 December 2014 OVERVIEW Cognitive Dispositions to Respond (CDRs) or cognitive biases are: “Predictable tendencies, or biases, to react to contextual clues that are largely unconscious and may contribute to flaws in reasoning; a mental state that embraces…
ILCOR Guideline Changes 2010
ILCOR = International Liaison committee on Resuscitation = conglomerate of resuscitation councils worldwide. Changes in 2010
Fluid bolus therapy
Fluid bolus therapy is widely administered to patients with undifferentiated hypotension and for patients with severe sepsis
Fluid Challenge
The fluid challenge (FC) aims at identifying patients in whom fluid administration improves haemodynamics (known as "fluid responsiveness")
Adaptive Trial Designs
An adaptive clinical trial involves a study design in which key characteristics are adjusted while enrollment in the trial is ongoing using prospectively defined decision rules and in response to information arising from the data accumulating in the trial
Blinding and Allocation Concealment
Blinding and allocation concealment are used in Randomised control trials (RCTs) to reduce systematic bias
Chi-square Test
Chi-square Test is used to compare categorical data; often displayed in contingency table with rows (x) and columns (y)