Enhanced Elimination
Enhanced elimination techniques serve to increase the rate of removal of an agent from the body with the aim of reducing the severity and duration of clinical intoxication.
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Ethanol Intoxication, Abuse and Dependence
Ethanol (ethyl alcohol) is an aliphatic alcohol, C2H5OH. The primary effect of ethanol is CNS depression, which is additive with other CNS depressants
High-dose Insulin Euglycaemic Therapy
High-dose Insulin Euglycaemic Therapy (HIET) is primarily used in the therapy of severe calcium channel blocker toxicity. HIET can also be used for severe beta blocker toxicity and potentially other toxicities/ presentations requiring inotropic support
How to conduct a clinical trial
Broad overview of the complicated process of conducting a clinical trial. Conducting a clinical trial can be conceptualised as having 14 key steps
Subgroup Analysis
Subgroup analysis involves assessing an association between an intervention (or other factor) and a subset of the patients that were exposed. Subgroup analysis can be decided upon a priori or performed post hoc
Before-and-after studies
Non-experimental observational study design used to assess the effect of an intervention based on comparison of outcomes prior to its use and afterward
Types of Research Studies
Types of study design arranged by level of evidence, from low to high
Bronchopleural Fistula
Bronchopleural fistula is an unnatural communication between the bronchial tree and pleural space as evidenced by continued leak post-pneumothorax. Can be life-threatening and difficult to manage
Decompression Sickness
Decompression sickness, is a form of decompression illness, where a reduction in ambient pressure ('decompression') leads to de no intravascular and extravascular bubble formation with pathological consequences
Medications and Thyroid Function
The effect of medications on thyroid function tests.
Pulse Oximeter
Pulse Oximeter: measurement of arterial oxygen-haemoglobin saturation (SaO2) — denoted SpO2 when measured by pulse oximetry
Pulmonary Embolism
Pulmonary embolism (PTE, PE) ranges from asymptomatic to a life threatening catastrophe. PE occurs when a deep vein thrombosis migrates to the pulmonary arterial tree