
Renal Transplant Patient
Renal Transplant; commonest transplant; anastamosed to common iliac artery and vein in the pelvis. the ureter is plumbed into the bladder; allows ease of access for palpation and biopsy
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.

Renal Transplant; commonest transplant; anastamosed to common iliac artery and vein in the pelvis. the ureter is plumbed into the bladder; allows ease of access for palpation and biopsy

AKI can be defined as an abrupt (1 to 7 days) and sustained (more than 24 hours) decrease in kidney function. The ADQI formulated the RIFLE criteria in 2004 to allow for AKI to be objectively and uniformly defined.

APACHE = Acute Physiology, Age and Chronic Health Evaluation (I-IV); SOFA = Sequential Organ Failure Assessment

Scoring systems commonly used in ICU: GCS; TISS; APACHE; SAPS; MPM; POSSUM; EuroSCORE; MELD and SOFA

Multiple Organ Dysfunction Syndrome (MODS) is a hypometabolic, immunodepressed state with clinical and biochemical evidence of decreased functioning of the body's organ systems that develops subsequent to an acute injury or illness.

Dosing is different to non-critically ill patients
Different antimicrobials have different kill characteristics, which can be demonstrated on a concentration vs time graph for antibiotic activity

See RCH Melbourne Guidelines:

Reviewed and revised 8 December 2014 OVERVIEW Cognitive Dispositions to Respond (CDRs) or cognitive biases are: “Predictable tendencies, or biases, to react to contextual clues that are largely unconscious and may contribute to flaws in reasoning; a mental state that embraces…

ILCOR = International Liaison committee on Resuscitation = conglomerate of resuscitation councils worldwide. Changes in 2010

Fluid bolus therapy is widely administered to patients with undifferentiated hypotension and for patients with severe sepsis

The fluid challenge (FC) aims at identifying patients in whom fluid administration improves haemodynamics (known as "fluid responsiveness")

An adaptive clinical trial involves a study design in which key characteristics are adjusted while enrollment in the trial is ongoing using prospectively defined decision rules and in response to information arising from the data accumulating in the trial