The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
An adaptive clinical trial involves a study design in which key characteristics are adjusted while enrollment in the trial is ongoing using prospectively defined decision rules and in response to information arising from the data accumulating in the trial
Blinding and allocation concealment are used in Randomised control trials (RCTs) to reduce systematic bias
Chi-square Test is used to compare categorical data; often displayed in contingency table with rows (x) and columns (y)
Obesity has multiple pathophysiological effects and leads to numerous multi-system complications
Bariatric Patient Hot Case
Reviewed and revised 24 May 2014 OVERVIEW MECHANISM OF ACTION TOXICOKINETICS RISK ASSESSMENT CLINICAL FEATURES Effects include: Complications INVESTIGATIONS (Guided by clinical assessment) Laboratory tests MANAGEMENT Resuscitation Supportive care and monitoring Decontamination Disposition References and Links Journal articles
Renal replacement therapy: Fluid Management
Enhanced elimination techniques serve to increase the rate of removal of an agent from the body with the aim of reducing the severity and duration of clinical intoxication.
Ethanol (ethyl alcohol) is an aliphatic alcohol, C2H5OH. The primary effect of ethanol is CNS depression, which is additive with other CNS depressants
High-dose Insulin Euglycaemic Therapy (HIET) is primarily used in the therapy of severe calcium channel blocker toxicity. HIET can also be used for severe beta blocker toxicity and potentially other toxicities/ presentations requiring inotropic support
Broad overview of the complicated process of conducting a clinical trial. Conducting a clinical trial can be conceptualised as having 14 key steps
Subgroup analysis involves assessing an association between an intervention (or other factor) and a subset of the patients that were exposed. Subgroup analysis can be decided upon a priori or performed post hoc