The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
OVERVIEW CLINICAL FEATURES INVESTIGATIONS MANAGEMENT -> ethanol dose (IV): 10% solution in D5W as a 40% solution, loading dose 7.5mL/kg -> 1-2mL/kg/hr-> ethanol dose (PO): quarter the above dose-> dose in CRRT: double IV dose-> maintain ethanol level @ 25-40mmol/L…
The Randomised Controlled Trial (RCT) is the 'gold standard' in evidence-based medicine, representing the highest levels of evidence
Aspiration pneumonitis, or Mendelson syndrome, is chemically induce inflammation of the lungs as a result of aspiration of gastric contents
Bronchiectasis
Sildenafil: potent selective phosphodiesterase inhibitor; inhibition of cGMP-specific phosphodiesterase -> pulmonary vasodilator
Rifampicin: inhibits DNA-dependent RNA polymerase activity
Prothrombinex: human plasma derivative; The 3 factor prothrombin complex concentrate available in Australia
Propofol: IV hypnotic agent; potentiates the inhibitory transmitters glycine & GABA which enhance spinal inhibition.
Indications Contraindications: Choose the correct catheter Handy Hints: References and Links
Sotalol: anti-arrhythmic; low doses = non-selective beta receptor antagonist; high doses = prolongs action potential
Statins (HMG CoA reductase inhibitors) are the most widely used drugs for lowering serum cholesterol levels. Statins also have anti-inflammatory, anti-oxidant and immune-modulating effects (ie independent lipid-lowering effects) which may attenuate end-organ dysfunction in a number of syndromes
Sugammadex is used for reversal of the amino steroid neuromuscular blocking drugs rocuronium, vecuronium and pancuronium.