- The Monro-Kellie doctrine or hypothesis states that the sum of volumes of brain, cerebrospinal fluid (CSF) and intracerebral blood is constant. An increase in one should cause a reciprocal decrease in either one or both of the remaining two.
- The doctrine is fundamental to our understanding of the negative effect of raised intracranial pressure on the brain.
1783 Alexander Monro, secundus published his observations on the structure and functioning of the nervous system. Given that the skull is a rigid compartment and the brain is “nearly incompressible”, Monro concluded that the amount of blood inside the skull should remain stable in normal and pathological conditions.
For, as the substance of the brain, like that of the other solids of our body, is nearly incompressible, the quantity of blood within the head must be the same, or very nearly the same, at all times, whether in health or disease, in life or after death, those cases only excepted, in which water or other matter is effused or secreted from the blood-vessels; for in these, a quantity of blood* equal in bulk to the effused matter, will be pressed out of the cranium. [Monro, secundus 1783]
1824 George Kellie; the Edinburgh based surgeon’s contribution to the doctrine stems from papers he published on the post mortem examination of two individuals that were found deceased in Leith the morning after a winter storm.
The circulation within the head is, in truth, of a very peculiar description. The brain itself, little compressible, is contained within a firm and unyielding case of bone, which it exactly fills and by which it is defended from the weight and pressure of the atmosphere (…) a force, therefore, that must be constantly operating to maintain the plenitude of the vascular system within the head. If these premises be true, it does not appear very conceivable how any portion of the circulating fluid can ever be withdrawn from the cranium, without its place being simultaneously occupied by some equivalent; or how any thing new or exuberant can be intruded, without an equivalent displacement. [Kellie, Dr Kellie On Death from Cold and on Congestions of the brain 1824]
1846 Burrows introduced some changes to this hypothesis in his book On the disorders of the cerebral circulation, postulating that cerebral blood volume may vary but only to the benefit or the detriment of brain and CSF volumes
- Did they first describe or popularise or plagiarise?
- Monro A. Observations on the structure and functions of the nervous system. Edinburgh: William Creech; 1783.
- Kellie G. On Death from Cold and on Congestions of the Brain. An account of the appearances observed in the dissection of two of three individuals presumed to have perished in the storm of the 3rd, and whose bodies were discovered in the vicinity of Leith on the morning of the 4th, November 1821: with some reflections on the pathology of the brain. Transactions of the Medico-Chirurgical Society of Edinburgh 1824;1:84-169
- Burrows G. On the disorders of the cerebral circulation. London: Longman, Brown, Green and Longmans. 1846
- Macintyre I. A hotbed of medical innovation: George Kellie (1770-1829), his colleagues at Leith and the Monro-Kellie doctrine. J Med Biogr. 2014 May;22(2):93-100. [PMID 24585579]List