Tag ethylene glycol
Toxicology-Library-Toxicant-Drug-340-256

Ethylene Glycol

Ethylene Glycol is lethal when >1 ml/kg is ingested therefore any deliberate ingestion need prompt intervention. Commonly found in radiator coolants, antifreeze (concentrations>20%), de-icing solutions, solvents and brake fluids. Unfortunately these products can taste sweet making them appealing to children.
Toxicology-Conundrum-340 256

Ethylene glycol inebriation

A 5 year-old boy is 'off his face' after drinking what looked like a nice bottle of cordial. It was actually radiator coolant. You are called for advice.
CCC Critical Care compendium 340

Toxic Alcohol Ingestion

Highlights and pearls on toxic alcohol ingestion from the EBMedicine article, "Toxic Alcohols: Not Always A Clear-Cut Diagnosis"
CCC Critical Care compendium 340

Ethylene Glycol Toxicity

OVERVIEW >1 mL/kg or a mouthful in a child is potentially lethal ethylene glycol itself is relatively non-toxic -> metabolites extremely toxic (glycolate) rate limiting step = alcohol dehydrogenase activity accumulation of glycolate -> direct cellular toxicity CLINICAL FEATURES drunk:…