Isoniazid overdose is rare but life threatening. Isoniazid can cause refractory seizures which require the specific antidote pyridoxine. It should be thought about in cases of status epileptics where this is a relative or a potential history of TB in the family.
Isoniazid toxicity, like other hydrazines, primarily cause life-threatening seizures and lactic acidosis through depletion of vitamin B6. The antidote is pyridoxine
What is tuberculosis (TB)? This tropical travel clinical case extravaganza covers aetiology, diagnosis, treatment and prevention of TB