Michael Denborough
Michael Antony Denborough (1929 – 2014) was an Australian anaesthetist, academic, activist and medical researcher. First described malignant hyperthermia (Maladie de Denborough)
Tag malignant hyperthermia
Toxidrome Challenge
Toxidrome challenge lets you test yourself on anticholinergic toxicity, malignant hyperthermia, neuroleptic malignant syndrome, and serotonin syndrome.
Malignant Hyperthermia
Malignant Hyperthermia = pharmacogenetic disease of skeletal muscle induced by exposure to certain anaesthetic agents; incidence 1:5,000 -> 1:65,000 anaesthetics (suspected); mutation in the gene coding for the ryanodine receptor
Hyperthermia-associated toxidromes
Toxidromes associated with hyperthermia may be difficult to distinguish: serotonin syndrome; anticholingeric syndrome; sympathomimetic syndrome; neuroleptic malignant syndrome; malignant hyperthermia