Michael Antony Denborough (1929–2014) was an Australian anaesthetist, academic, politician and medical researcher.
First described malignant hyperthermia (Maladie de Denborough)
Co-founder of Nuclear Disarmament Party in 1984. He is known to have maintained a solo vigil outside the parliament house in Canberra (Australia) for a total of 52 days against the war in Iraq. He was arrested twice in his lifetime; once in 1991 for protesting at an arms bazaar and second time outside the French Embassy after the French government resumed their nuclear tests in the Pacific.
In 2003 he was dismissed from Parliament for protesting loudly in the gallery when John Howard (Australian Ex-Prime Minister) committed Australian troops for the Iraq invasion.
- Born on July 11, 1929 in Salisbury, Rhodesia (now Harare, Zimbabwe)
- 1952 – Graduated in Medicine at the University of Cape Town, South Africa
- 1956 – Obtained his DPhil (Doctor of Philosophy) from Oxford University, England
- 1958 – Began his residency at National Heart Hospital, London, United Kingdom
- 1960 – Moved to Australia – with wife Erica and commenced work at the Royal Melbourne Hospital. Denborough led an investigation a family with general anaesthesia related deaths and coined the term malignant hyperpyrexia (MH) in a letter published in the Lancet in 1960
- 1972 – Eric Susman Prize awarded from Royal Australian College of Physicians (RACP)
- 1974 – Moved to John Curtin School of Medical Research in Canberra, Australia for further research into MH and related muscle disorders as a professorial fellow
- 1982 – Gold medal awarded at the Fifth International Congress on Neuromuscular Diseases in Marseilles
- 1992 – Professor at the John Curtin School of Medical Research at the Australian National University
- 1995 – Retired to a role of Emeritus Professor
- 1999 – Appointed a member of the order of Australia for service to medicine
- Died on February 8, 2014 in Melbourne, Australia
Maladie de Denborough (1960) (malignant hyperthermia)
Malignant hyperthermia = pharmacogenetic disease of skeletal muscle induced by exposure to certain anaesthetic agents
- incidence 1:5,000 -> 1:65,000 anaesthetics (suspected)
- mutation in the gene coding for the ryanodine receptor
- autosomal dominant
In April 1960, at the Royal Melbourne Hospital, anaesthetist Dr Jim Villiers treated a patient who was understandably terrified as 10 members of his family had died during other minor procedures involving general anaesthesia. The patient, a 21-year-old engineering student had suffered a compound fracture of his right tibia and required general anaesthesia for the open reduction and internal fixation to be performed. Dr. Villiers decided to administer halothane and utilise all available monitors at the time. Whilst the fracture was quickly reduced and closed, the patient developed tachycardia, hypotension, hypoxemia and hyperthermia.
Dr. Villiers initially thought this may be due to blood loss from the fracture and the patient was given a blood transfusion. Subsequently as the patient deteriorated Dr. Villiers packed the patient in ice being used in a nearby cardiac theatre and the patient was awake and alert with an uneventful subsequent hospital stay. While his patient did develop signs of what we now refer to as Malignant Hyperthermia, Dr Villiers was able to save him from the fate of his other relatives with his skilled anaesthetic management.
Dr Michael Denborough and his colleague Dr Richard Lovell then went on to study this patients family in greater detail. They outlined the autosomal dominant inheritance of this severe reaction to anaesthetics and their letter was published in The Lancet. Dr Denborough went on to devote most of his career to research in the field of malignant hyperthermia.
King-Denborough syndrome (1970)
King-Denborough syndrome (KDS) is an autosomal dominant disorder characterized by the triad of congenital myopathy, dysmorphic features, and susceptibility to malignant hyperthermia. Caused by heterozygous mutation in the RYR1 gene (180901) on chromosome 19q13
- Denborough MA et al. Anaesthetic deaths in a family. Br J Anaesth. 1962 Jun;34:395-6.
- Denborough MA, Levell RRH. Anaesthetic deaths in a family. Lancet 1960; 276(7140): 45
- Denborough MA, Ebeling P, King JO, Zapf P. Myopathy and malignant hyperpyrexia. Lancet. 1970; 295(7657): 1138-1140
- King JO, Denborough MA, Zapf PW. Inheritance of malignant hyperpyrexia. Lancet. 1972; 1(7746): 365-70.
- King JO, Denborough MA. Anesthetic-induced malignant hyperpyrexia in children. J Pediatr. 1973; 83(1): 37-40.
- Moulds RF, Denborough MA. Biochemical basis of malignant hyperpyrexia. Br Med J. 1974; 2(5913): 241-4.
- Denborough MA, Galloway GJ, Hopkinson KC. Malignant hyperpyrexia and sudden infant death. Lancet. 1982; 320(8307): 1068-9.
- Denborough MA, Collins SP, Hopkinson KC. Rhabdomyolysis and malignant hyperpyrexia. Br Med J (Clin Res Ed). 1984 Jun 23;288(6434):1878.
- Denborough MA. Malignant hyperthermia. 1962. Anesthesiology. 2008 Jan;108(1):156-7.
- Denborough MA. Malignant hyperthermia. Lancet. 1998; 352(9134): 1131-1136
In 1970 Michael came across evidence of an increase of radioactive iodine uptake in sheep’s thyroid glands every time the French conducted a nuclear test in the Pacific. When the politicians refused to act on this information he and his medical colleague Roger Melick wrote a press release and sent it to all the national newspapers. The Australian public was horrified and the outburst led to the matter being taken up by the newly elected Gough Whitlam. He then sent his attorney-general Lionel Murphy to the International Court in the Hague and that forced the French nuclear tests underground.5
Michael’s activism continued throughout the years. He was arrested for protesting at AIDEX (an arms bazaar) in 1991 and then again in the mid 90s outside the French Embassy after the French government resumed their nuclear tests in the Pacific.5
In 2003 when the US invaded Iraq he set up a solo vigil outside Parliament House in Canberra and stayed for 52 days. On the day Howard committed Australian troops to Iraq he got thrown out of Parliament for protesting loudly from the gallery.5
- Reed UC et al. King-Denborough Syndrome: report of two Brazilian cases. Arq Neuropsiquiatr. 2002 Sep;60(3-B):739-41.
- Maltby R. Notable Names in Anaesthesia. The Choir Press 2013: 46-48
- Remembering Malignant Hyperthermia Pioneer: Michael Denborough, MD. NewsWire ID:613815. 14-Feb-2014
- Gillies R. Professor Michael A Denborough AM (1929-2014). ANZCA 2014
- Denborough L. Obituary: Michael Denborough. The Greens. 2014 June
- Bibliography. Denborough, Michael. WorldCat Identities
- Kaur H, Katyal N, Yelam A, Kumar K, Srivastava H, Govindarajan R. Malignant Hyperthermia. Mo Med. 2019 Mar-Apr;116(2):154-159.
the person behind the name
Associate Professor Curtin Medical School, Curtin University. Emergency physician MA (Oxon) MBChB (Edin) FACEM FFSEM Sir Charles Gairdner Hospital. Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |