Tag pathophysiology

Going back to extremes!

The Leaderboard for 'extremes' from the real world of clinical pathophysiology! Seven years ago, thanks to a suggestion by Greg Kelly, we sought out the most extreme parameters clinicians have encountered in looking after their patients.
CCC Critical Care compendium 340

Sepsis Pathophysiology

OVERVIEW Organisms Bacteria-> Gram +ve’ cocci (staphylococci, streptococci)-> Gram –ve bacilli (E.coli, Klebsiella, Pseudomonas aeruginosa) Fungi (Candida) Viruses Parasites Complex interaction between inciting microbe host immune response inflammatory pathway coagulation pathway LPS = lipopolysaccharideTRAF6 = TNF receptor-associated factor 6NIK =…