Hugh Spear Pemberton (1890-1956) was an English physician. Pemberton's description of the eponymous Pemberton Sign appeared in a brief letter to The Lancet in 1946
Obstruction of the superior vena cava results from mediastinal mass lesions. Features include a plethoric and cyanosed face with periorbital oedema, exophthalmos, conjunctival injection, and venous dilatation in the fundi, distended non-pulsatile neck veins and a positive Pemberton sign.
Superior vena cava (SVC) obstruction impairs venous return through the SVC to the right atrium and has many causes, usually mediastinal masses or complications of SVC lines