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Tag Salicylate
Toxicology-Library-Toxicant-Drug-340-256

Salicylate toxicity

Salicylates in acute overdose classically cause a respiratory alkalosis by stimulating the respiratory centres in the brain followed by a metabolic acidosis by uncoupling oxidative phosphorylation. The classic triad of mild toxicity is nausea, vomiting and tinnitus,
CCC Critical Care compendium 340

Salicylate Poisoning

Salicylate poisoning: mechanisms of toxicity: acid-base disturbance, uncoupling of oxidative phosphorylation, disordered glucose metabolism