Tag Salicylate

Salicylate toxicity

Salicylates in acute overdose classically cause a respiratory alkalosis by stimulating the respiratory centres in the brain followed by a metabolic acidosis by uncoupling oxidative phosphorylation. The classic triad of mild toxicity is nausea, vomiting and tinnitus,
CCC Critical Care compendium 340

Salicylate Poisoning

Salicylate poisoning: mechanisms of toxicity: acid-base disturbance, uncoupling of oxidative phosphorylation, disordered glucose metabolism