Phenytoin intoxication can occur either with repeated supra therapeutic dosing or an acute overdose. Dose-dependent CNS depression occurs. Most presentations are benign and have good outcomes with supportive care. The main risk to patients is falling which can last days.
AGENTS NB. phenytoin and sodium valproate do not usually present with features of sodium channel blockade in overdose. CLINICAL FEATURES INVESTIGATIONS SPECIFIC MANAGEMENT AND TRIGGERS FOR INTERVENTION References and Links
Tricyclic Antidepressants (TCA) are weak bases (pKa 8.5) that can cause life-threatening sodium channel toxicity