Toxic Alcohol Ingestion
Highlights and pearls on toxic alcohol ingestion from the EBMedicine article, "Toxic Alcohols: Not Always A Clear-Cut Diagnosis"
OVERVIEW >1 mL/kg or a mouthful in a child is potentially lethal ethylene glycol itself is relatively non-toxic -> metabolites extremely toxic (glycolate) rate limiting step = alcohol dehydrogenase activity accumulation of glycolate -> direct cellular toxicity CLINICAL FEATURES drunk:…