Xeroderma pigmentosum (XP): rare autosomal recessive disorder of DNA repair characterised by photosensitivity, progressive pigmentary change, and an increased incidence of ultraviolet (UV)-induced skin and mucous membrane cancers.
Ciprofloxacin: quinolone antibiotic; inhibition of enzymes required for bacterial DNA replication, transcription, repair and recombination.
Error in research can be systematic or random; systematic error is also referred to as bias
Kaposi Sarcoma: An idiopathic pigmented sarcoma of the skin. Red nodules of varying size develop in the skin initially appearing on the sole of the foot then affecting the hands, progressing to affect the rest of the body.
Moriz 'Kohn' Kaposi (1837 – 1902) was a Hungarian physician and dermatologist. Provided first, descriptions of systemic lupus erythematosus (1869/1872); Kaposi Sarcoma (1872); xeroderma pigmentosum (1882); lichen ruber moniliformis (1886); and varicelliform eruption (1887)
Question A two-week-old baby is brought to your general ICU in extremis pending transfer to a paediatric centre. Born at term, she had been discharged well on day 5 of life. For three days she has had progressive tachypnoea, lethargy…
Reviewed and revised Chris Nickson and Sarah Yong STEROIDS AND TBI Roberts I, Yates D, Sandercock P, et al: CRASH trial collaborators: Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC…
Troubleshooting Pulmonary Artery Catheter insertion
Therapeutic drug monitoring (TDM) is the individualization of drug dosage by maintaining plasma or blood drug concentrations within a target range (the 'therapeutic window')
Paracetamol (acetaminophen, APAP) is an ubiquitous analgesic and antipyretic agent; its safety and efficacy in critical illness?
This ECG is from a 49 year old. He self-presented to the emergency department with chest pain. Describe and interpret this ECG. LITFL Top 100 ECG
Apnoeic oxygenation is used to extend the 'safe apnoea time' beyond that which can be achieved by preoxygenation alone