Coarctation of Aorta
Coarctation of Aorta: congenital condition characterised by narrowing of the aorta near the site where the ductus arteriosus (ligamentum arteriosum after regression) inserts.
Month January 2019
Superior Vena Cava (SVC) Obstruction
Superior vena cava (SVC) obstruction impairs venous return through the SVC to the right atrium and has many causes, usually mediastinal masses or complications of SVC lines
Pulmonary Toxicity of Chemotherapy
Pulmonary Toxicity of Chemotherapy
Neurological Toxicity of Chemotherapy
Neurological Toxicity of Chemotherapy: Encephalopathy; Cerebellar Syndrome; Myelopathy; Peripheral Neuropathy; Stroke and Venous Thrombosis; SIADH
Metabolic Toxicity of Chemotherapy
Metabolic Toxicity of Chemotherapy: Disorders related to the Tumour; disorders related to Anticancer Agents
Coagulation Profile
OVERVIEW PROTHROMBIN TIME -> warfarin-> vitamin K deficiency-> liver disease-> DIC-> artefact: incorrect sampling or increased haematocrit (> 55%) ACTIVATED PARTIAL THROMBOPLASTIN TIME -> heparin-> DIC-> haemophilia-> liver disease THROMBIN TIME -> heparin-> DIC-> hypofibrinogenaemia-> fibrin degradation products FIBRINOGEN ->…
D-dimer
D-dimer specific for fibrin breakdownsensitivity = 95%specificity = 50%
Full Blood Count
FBC - full blood count; FBE - full blood examination; FBP - full blood picture
Platelet Function Assays
PFA-100 = citrated whole blood placed in a disposable cartridge containing a membrane coated with collagen/adrenaline or collagen/ADP into which a microscopic aperture has been cut -> with high shear rates contact of blood with the membrane causes platelets to aggregate and occlude the aperture.
Thromboelastogram (TEG)
Thromboelastography (TEG) is a viscoelastic hemostatic assay that measures the global viscoelastic properties of whole blood clot formation under low shear stress
Thrombophilia Screen
Thrombophilia is a predisposition to increased risk of venous and arterial thromboembolism due to haemostatic abnormalities