Ideal Helicopter Ventilator
Ideal helicopter ventilator
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Sepsis Biomarkers
Reviewed and revised 20 December 2015 OVERVIEW At least 178 different sepsis biomarkers have been described in the published medical literature, reflecting the complex pathophysiology of sepsis e.g. coagulation, complement, contact system activation, inflammation, and apoptosis also biomarkers of complications, e.g.…
Arthritis DDx
Arthritis is inflammation of a joint (redness, warmth, pain, swelling, loss of function) that may be acute or chronic, and affect one or multiple joints.
Lithium Toxicity
Lithium: acute overdose is usually benign if adequate hydration is maintained and renal function is normal; chronic toxicity can be difficult to manage and result in devastating neurotoxicity
Methylene Blue
CLASS MECHANISM OF ACTION (1) low concentrations: methylene blue -> NADPH-dependent reduction to leucomethylene blue (due to action of methaemoglobin reductase) -> reduces methaemoglobin -> Hb(2) high concentrations: methylene blue -> converts ferrous iron of reduced Hb to ferric ion…
Hilar adenopathy DDx
Hilar lymphadenopathy, seen on chest x-ray or chest CT, can be classified as unilateral or bilateral, and if bilateral as symmetrical or asymmetrical.
Validity of Research and Measurements
OVERVIEW In general terms, validity is “the quality of being true or correct”, it refers to the strength of results and how accurately they reflect the real world. Thus ‘validity’ can have quite different meanings depending on the context! Reliability…
Aspiration Pneumonia
Aspiration Pneumonia = aspiration of oropharyngeal contents which includes colonizing flora and leads to infection.
Propofol-related Infusion Syndrome
Propofol-related Infusion Syndrome is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole
Sodium Valproate
Sodium Valproate: anticonvulsant; decreasing neuronal excitability or enhancing inhibition of neuronal transmission.
Protamine
Protamine: neutralization of heparin. Strongly basic protamine + strongly acid heparin -> forms stable salt -> removed by reticuloendothelial system.
Prostacyclin or Epoprostenol
Prostacyclin or Epoprostenol: -> used in the treatment of RV failure and pulmonary hypertension