Meropenem
Meropenem: carbapenem; inhibits cell wall synthesis; empiric treatment for severe sepsis
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Thickened tethered skin DDx
Thickened tethered skin is usually suggestive of an underlying rheumatological/ immune condition.
Midazolam
Midazolam: imidazobenzodiazepine; act via benodiazepine receptor in CNS; linked and facilitate action of the GABA receptor; chloride channel activation -> hyperpolarises membrane.
Milrinone
Milrinone: bipyridine; non receptor mediated inhibitor of cAMP phosphodiesterase III isoenzyme -> decrease the hydrolysis of cAMP; increase cAMP (analogous to activating a Gs protein)
Morphine
Morphine: opioid analgesic; mu and kappa receptor agonist; increase intracellular Ca2+ -> increased K+ conductance -> hyperpolarisation of excitable cell membranes -> decrease in pre & post synaptic responses; reversed by naloxone
N-acetylcysteine
N-acetylcysteine (NAC): glutathione supplementation ? protects the liver by maintaining and restoring glutathione levels or by acting as an alternate substrate for conjugation with -> detoxification of reactive metabolites.
Naloxone
Naloxone: opioid receptor antagonist; competitive antagonism at mu, kappa and delta receptors -> prevention of binding to endogenous and exogenous opiate receptors.
Noradrenaline
Noradrenaline (norepinephrine) hypotension refractory to fluid resuscitation (primarily distributive shock such as septic shock, neurogenic shock, post-bypass vasoplegia and drug-induced)
NSAIDs
NSAIDS: Nonsteroidal anti-inflammatory drugs; non-selective COX inhibitors
Octreotide
Octreotide: somatostatin analogue; reduces portal hypertension; antidote to sulfonylureas; reduces GI secretions
Omeprazole
Omeprazole: proton pump inhibitor; inhibits Na-H+ exchanger in parietal cell membrane
Opioids
An opioid is any psychoactive chemical that resembles opiates in their pharmacological effects by binding opioid receptors. They may be endogenous or exogenous compounds, and may be naturally occurring or synthetic