Paediatric Vital Signs
Very simplified pediatric vital signs table
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Persistent Pulmonary Hypertension in the Newborn
Persistent Pulmonary Hypertension in the Newborn
Physiological Changes At Birth
Physiological Changes At Birth
Tetralogy of Fallot
Tetralogy of Fallot: Large VSD; RV outflow tract obstruction; RV hypertrophy; and Overriding aorta
Serious skin signs in sick patients
In emergency medicine and critical care it is essential to be able to recognise skin signs that signify serious disease, and be able to consider the likely causes.
Hirsutism DDx
Hirsutism is abnormal growth of hair on a person's face and body, especially in females.
Splinter haemorrhages DDx
Splinter hemorrhages are lesions caused by linear bleeding under a fingernail or toenail, resembling a splinter.
Meropenem
Meropenem: carbapenem; inhibits cell wall synthesis; empiric treatment for severe sepsis
Thickened tethered skin DDx
Thickened tethered skin is usually suggestive of an underlying rheumatological/ immune condition.
Midazolam
Midazolam: imidazobenzodiazepine; act via benodiazepine receptor in CNS; linked and facilitate action of the GABA receptor; chloride channel activation -> hyperpolarises membrane.
Milrinone
Milrinone: bipyridine; non receptor mediated inhibitor of cAMP phosphodiesterase III isoenzyme -> decrease the hydrolysis of cAMP; increase cAMP (analogous to activating a Gs protein)
Morphine
Morphine: opioid analgesic; mu and kappa receptor agonist; increase intracellular Ca2+ -> increased K+ conductance -> hyperpolarisation of excitable cell membranes -> decrease in pre & post synaptic responses; reversed by naloxone