Cato H. J. van Lohuizen (1893 - 1937)

Cato H. J. van Lohuizen (1893 – 1937) was a Dutch pediatrician.

van Lohuizen studied medicine at the University of Amsterdam and became the first female pediatrician in the Netherlands. Her pediatriac practice was located on Ministerspark.

She is eponymously remembered for her description of Cutis Marmorata Telangiectatica Congenita (CMTC), or Van Lohuizen syndrome (1922).

Medical Eponyms
Van Lohuizen syndrome (1922)

[aka Cutis Marmorata Telangiectatica Congenita (CMTC)]

Cutis marmorata telangiectatica congenita (CMTC, Van Lohuizen syndrome) is a rare congenital vascular anomaly of unknown aetiology in newborn or very young children. Around 300 cases have been reported in the literature. The rate of associated anomalies varies between 20% and 70%. From the dermatological point of view, therapy is either not necessary or uncomplicated. However, the treating physician should search for possibly associated anomalies.

Severe form of Van Lohuizen syndrome with ulceration
Severe form of Van Lohuizen syndrome with ulceration. CMTC OVM

Clinical presentation includes persistent cutis marmorata (marbled or mottled skin appearance caused by low-flow, prominent, coarsely reticulated, violaceous capillary malformations); telangiectases; venous dilatations or phlebectasias; and rarely superficial ulceration and atrophy of the involved skin. Cold exposure usually makes the lesions more prominent, however warming of the skin does not make them disappear. This differentiates CMTC from physiologic cutis marmorata (occurring in neonates upon cold exposure) which is reversible by skin warming.

Van Lohuizen syndrome CMTC skin warming
No response of cutis marmorata to skin warming in Van Lohuizen syndrome. CMTC OVM

Major Publications



Eponymous Terms

Graduated from Cardiff Medical School in 2017 with MBBCh and BSc in Psychology and Medicine. Currently working as a doctor in the emergency department at Sir Charles Gairdner Hospital in Perth, Australia.

BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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