Cato H. J. van Lohuizen (1893 – 1937) was a Dutch pediatrician.
van Lohuizen studied medicine at the University of Amsterdam and became the first female pediatrician in the Netherlands. Her pediatriac practice was located on Ministerspark.
She is eponymously remembered for her description of Cutis Marmorata Telangiectatica Congenita (CMTC), or Van Lohuizen syndrome (1922).
Van Lohuizen syndrome (1922)
[aka Cutis Marmorata Telangiectatica Congenita (CMTC)]
Cutis marmorata telangiectatica congenita (CMTC, Van Lohuizen syndrome) is a rare congenital vascular anomaly of unknown aetiology in newborn or very young children. Around 300 cases have been reported in the literature. The rate of associated anomalies varies between 20% and 70%. From the dermatological point of view, therapy is either not necessary or uncomplicated. However, the treating physician should search for possibly associated anomalies.
Clinical presentation includes persistent cutis marmorata (marbled or mottled skin appearance caused by low-flow, prominent, coarsely reticulated, violaceous capillary malformations); telangiectases; venous dilatations or phlebectasias; and rarely superficial ulceration and atrophy of the involved skin. Cold exposure usually makes the lesions more prominent, however warming of the skin does not make them disappear. This differentiates CMTC from physiologic cutis marmorata (occurring in neonates upon cold exposure) which is reversible by skin warming.
- Van Lohuizen CHJ. Über eine seltene angeborene Hautanomalie (Cutis marmorata telangiectatica congenita) Acta dermato-venereologica. 1922; 3: 202-211
- Dr. van Lohuizen. CMTC-OVM
- Pehr K, Moroz B. Cutis marmorata telangiectatica congenita: long-term follow-up, review of the literature, and report of a case in conjunction with congenital hypothyroidism. Pediatr Dermatol. 1993 Mar;10(1):6-11.
- Rupprecht R, Hundeiker M. Cutis marmorata teleangiectatica congenita. Wichtige Aspekte für die dermatologische Praxis [Cutis marmorata teleangiectatica congenita. Important aspects for dermatologic practice]. Hautarzt. 1997 Jan;48(1):21-5.
- Kienast AK, Hoeger PH. Cutis marmorata telangiectatica congenita: a prospective study of 27 cases and review of the literature with proposal of diagnostic criteria. Clin Exp Dermatol. 2009 Apr;34(3):319-23.
- Happle R. Capillary malformations: a classification using specific names for specific skin disorders. J Eur Acad Dermatol Venereol. 2015 Dec;29(12):2295-305
- Bui TNPT, Corap A, Bygum A. Cutis marmorata telangiectatica congenita: a literature review. Orphanet J Rare Dis 2019; 14: 283
- Wollina U, França K, Lotti T, Tchernev G. Van Lohuizen Syndrome – A Case Report with a Diagnostic Delay of Four Years. Open Access Maced J Med Sci. 2018;6(1):74-75.
Graduated from Cardiff Medical School in 2017 with MBBCh and BSc in Psychology and Medicine. Currently working as a doctor in the emergency department at Sir Charles Gairdner Hospital in Perth, Australia.
BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Associate Professor Curtin Medical School, Curtin University. Emergency physician, Sir Charles Gairdner Hospital. Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |