Jean-François Kérandel

Jean Francois Kerandel (1873-1934) was a French physician.

Author of Kerandel sign and symptom in African human trypanosomiasis

  • Born 1873
  • 1896 – Graduated medicine l’Ecole du service de santé de la marine de Bordeaux
  • 1899 – MD Thesis
  • 1903 – Company medic for the Colonial troops, Madagascar
  • 1906 – Studied tropical medicine in Haut Logone, Congo
  • Professeur Ecole d’Application Service Santé Troupes coloniales, Pharo, Marseille.
  • Directeur de l’Institut Pasteur de Téhéran
  • Died 20th July 1934

Medical Eponyms

Kérandel sign (1908) [* hyperesthésie profonde] Deep hyperaesthesia accompanied by pain, often delayed, after slight blow upon a bony projection of the body. Symptom of African human trypanosomiasis. Attributed ‘le signe de Kérandel’ in 1908 by Martin et Darré

Kérandel symptom [* signe de la clef] is a sharp, deep pain in the bones or muscles when a patient with sleeping sickness turns a key in a lock. Symptom of African human trypanosomiasis. Symptom first described by Heckenroth and Ouzilleau in 1907

Lycus kerandeli (1909)

Cicindela kerandeli (1909)


Kérandel became infected with trypanosomiasis (April 1907) and self treated with prolonged course of antimony potassium tartrate [Bull. Soc. Path. Exot 1910;3:642]

There are two distinct symptoms of African human trypanosomiasis variably attributed to Kerandel.

  • The deep hyperaesthesia which occurs in the early stage of the disease is termed Kerandel sign, having been described by Kerandel in 1908.
  • The “signe de la clef” (sign of the key) is a pain in the bones or muscles when the sleeping sickness patient turns a key in a lock. It is often referred to as Kerandel symptom however it was first described by Ferdinand Heckenroth (1880-1959) and Francis Ouzilleau ( – 1963) in 1907. [1911;14:335]

Major Publications


BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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