Ludwig angina: rapidly progressive gangrenous bilateral cellulitis of the submandibular space and soft tissues of the neck with risk of life-threatening airway compromise. Ludwig angina can rapidly lead to an airway obstruction and death with a mortality rate of up to 50% in untreated cases and 8% for treated disease.
The condition is named after the German physician Wilhelm Frederick von Ludwig (1790–1865) following his 1836 description
History of Ludwig angina
Early descriptions of deep neck infections date back to Hippocrates and Galen.
1769 – John Fothergill (1712–1780)
1822 – George Gregory (1790-1853) Physician to the Small-Pox and Vaccination Hospital. cynanche (Greek: kyōn “dog” – ankhein “to strangle”; “dog collar”)
1836 – Willhem Frederick von Ludwig described five patients with pronounced neck swelling that progressed rapidly to involve the tissues between the larynx and the floor of the mouth. “gangrenous indurations of the connective tissues of the neck that advanced to involve the tissues that cover the small muscles between the larynx and the floor of the mouth”.
His first patient was Queen Catherine of Württemberg.
1837 – Ludwig’s Stuttgart colleague, Dr. Camerer in Langeuau Angina Ludovici (Latin angere “to throttle, torment”) https://reader.digitale-sammlungen.de/de/fs1/object/display/bsb10054236_00093.html
1890 – William Morrant Baker (1839 – 1896)
The name by which the several forms of submaxillary cellulitis have been chiefly known of late years (angina Ludovici) is an unfortunate one. It has the disadvantage, common to all cases in which a disease is named after its supposed first observer, of giving no clue to the nature or site of the malady; and, in this instance, the term is not appropriate in any sense, inasmuch as Ludwig of Stuttgart, after whom it is named, was not the first author who described it. His description of the disease, for which he proposed the term “gangrenous induration of the cellular tissue of the neck,” appeared in the year 1836; but a well-marked example of the affection had been recorded some years previously (1822) by Dr. GregoryBaker 1890
- George Gregory (1790-1853)
- Wilhelm Frederick von Ludwig (1790–1865)
- William Morrant Baker (1839 – 1896)
- Angina Ludovici, Ludwig’s angina
- Cynanche cellularis of Gregory
- Fothergill J. An account of the putrid sore throat. 1769
- Gregory G. Case of Cynanche Cellularis With Remarks. The London medical and physical journal. 1822; 48: 287-290
- Von Ludwig WF. Über eine in neuerer Zeit wiederholt hier vorgekommene Form von Halsentzündung. Medicinisches Correspondenzblatt des Württembergischen ärztlichen Vereins, Stuttgart, 1836; 6(4): 21–25.
- Recherches sur une espèce particulière d’angine. Observation du Docteur Ludwig. Gazette médicale de Paris. 1836; 4(37): 577-581
- Ludwig WF. Ueber eine neue Art von Halsentzündung, Schmidt’s Jahrbücher 1837; 15(35): 25-27
- Camerer. Ein Beitrag zur Geschichte derjenigen Form von Halsentzündung welche Herr Leibmedicus v. Ludwig zuerst beschrieben hat. Medicinisches Correspondenzblatt des Württembergischen ärztlichen Vereins, Stuttgart, 1837; 7(10): 73-78.
- Murchison F. A Note on Angina Ludovici. Br Med J. 1875; 2(782): 778-779
- Doig A. Angina Ludovici. Br Med J. 1876; 1(798): 475-476
- Baker WM. Submaxillary cellulitis: syn. cynanche cellularis of Gregory, angina externa, angina Ludovici, cynanche sublingualis rheumatico-typhoides. 1890
- Ross GG. VII. Angina Ludovici. Ann Surg. 1901; 33(6): 720-725
- Burke J. Angina Ludovici: a translation, together with a biography of Wilhelm Frederick von Ludwig. Bulletin of the History of Medicine. 1939; 7(9): 1115–1126.
- McCaskey CH. Ludwig’s angina. Arch Otolaryngol. 1942; 36(4): 467-472
- Hall SF. Ludwig’s-like angina (pseudo-angina Ludovici). J Otolaryngol. 1984; 13(5): 321-324
- Nguyen VD, Potter JL, Hersh-Schick MR. Ludwig angina: an uncommon and potentially lethal neck infection. AJNR Am J Neuroradiol. 1992; 13(1): 215-219
- Hulme P. Ludwig’s Angina. St Emlyn’s
the names behind the name