Mirizzi syndrome


  • Mirizzi syndrome or extrinsic biliary compression syndrome, is a rare complication of cholelithiasis
  • Mirizzi syndrome is characterised by obstruction of the common bile duct (CBD), secondary to mechanical compression caused by the impaction of one or multiple gallstones in the neck of the gallbladder or cystic duct
  • The prevalence of this rare complication varies from 0.05 to 3%,7,8 and is more frequent in women
  • Patients usually present with obstructive jaundice that may be associated with abdominal pain and fever


1905 – First described by Kehr

1908 – Further description by Ruge

1948 – Mirizzi

Associated Persons

Alternative names

  • Name
  • Name


  • Kehr H. Die in neiner klinik geubte technik de gallenstein operationen, mit einen hinweis auf die indikationen und die dauerersolge. Munchen: JF Lehman; 1905.
  • Ruge E. Deitrage zur chirurgischen anatomie der grossen galenwege (Ductus hepaticus, choledochus, und pancreaticus) Arch Clin Chir. 1908;78:47.
  • Mirizzi PL. Sindrome del conducto hepatico. J Int Chir. 1948;8:731–777.
  • Abou-Saif A, Al-Kawas FH. Complications of gallstone disease: Mirizzi syndrome, cholecystocholedochal fistula, and gallstone ileus. Am J Gastroenterol. 2002 Feb;97(2):249-54. [PMID 11866258]
  • Becker CD. Preoperative diagnosis of the Mirizzi syndrome: limitations of sonography and computed tomography. AJR Am J Roentgenol. 1984 Sep;143(3):591-6. [PMID 6331740]
  • Payá-Llorente C et al. Mirizzi syndrome: a new insight provided by a novel classification. Ann Hepatobiliary Pancreat Surg. 2017 May; 21(2): 67–75. [PMC5449366]

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Emergency physician MA (Oxon) MBChB (Edin) FACEM FFSEM with a passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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