Reye syndrome

  • What is the actual eponymous medical sign/syndrome/repair/classification…


1929 – First recorded

1963 – Reye, Morgan and Baral published in Lancet

1964 – George Johnson published after Influenza B outbreak

1979 – Starko et al statistically-significant link between aspirin use and Reye syndrome

1980 – CDC cautioned physicians and parents about the association between Reye syndrome and the use of salicylates in children and teenagers with chickenpox or virus-like illnesses

1986 – FDA warning label for aspirin-containing medications

Associated Persons

Alternative names
  • Reye’s syndrome
  • Reye-Johnson syndrome

  • Reye RD, Morgan G, Baral J. Encephalopathy and fatty degeneration of the viscera. A Disease entity in childhood. Lancet. 1963 Oct 12;2(7311):749-52. [PMID 14055046]
  • Johnson GM, Scurletis TD, Carroll NB: A study of sixteen fatal cases of encephalitis-like disease in North Carolina children. N C Med J. 1963 Oct;24:464-73. [PMID 14053538]
  • Starko KM, Ray CG, Dominguez LB, Stromberg WL, Woodall DF.. Reye’s syndrome and salicylate use. Pediatrics. 1980 Dec;66(6):859-64. [PMID 7454476]
  • Aspirin and Reye syndrome. Committee on Infectious Diseases. Pediatrics. 1982 Jun;69(6):810-2 [PMID 7079050]
  • Mowat AP. Reye’s syndrome: 20 years on. Br Med J (Clin Res Ed). 1983 Jun 25;286(6383):1999-2001. [PMC1548508]
  • Orlowski JP. Reye’s Syndrome — A Modern Medical Mystery. In: Prakash O. (eds) Critical Care of the Child. Developments in Critical Care Medicine and Anesthesiology. 1984;8:115-125. Springer, Dordrecht


the names behind the name

BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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