ACEM Primary Pharmacology of Carbamazepine: the Pharmacokinetics; Pharmacodynamics; Clinical uses; Adverse effects
Carbamazepine overdose has a predictable dose-dependent CNS depression and anticholinergic effects. Carbamazepine if unique in the anticonvulsants that is also has sodium channel blocking effects and can act similarly in overdose to a tricyclic antidepressant and the role of sodium bicarbonate should be remembered.
It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 270
A 41-year old man is brought to ED after becoming drowsy while in police custody. He states that he has taken an overdose of diazepam tablets prior to being arrested. A puzzling case of drug-induced delirium. Can you solve the mystery?
Massive carbamazepine overdose (> 50mg/kg) is associated with cardiotoxicity due to fast sodium channel blockade.