Tag clozapine
Network Five Journal Club Podcast 340

Network Five: Toxicology

Network Five Emergency Medicine Journal Club Episode 19 - Toxicology reviewing papers on chemical warfare agents, Clozapine and drug overdose in pregnancy.

Clozapine toxicity

Clozapine is an atypical antipsychotic, due to its restricted use an acute overdose is a rare event but clinicians should be aware that coma can occur and management is with supportive care. In chronic toxicity agranulocytosis and myocarditis can occur, these are not features of an acute poisoning but monitored in patients with long term therapeutic use.
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Seizures, Sedation and Saliva

A 21-year-old male with a background of schizophrenia and previous intentional overdose, weighing 70kg, was brought to the ED via ambulance after having a witnessed seizure at home.