Stevens-Johnson syndrome is an immunological skin conditions, often secondary to drugs or infection.
A 22 year old woman with a past history of a seizure disorder presents to the ED with a 3 day history of progressive rash and fever. The rash began as macules and papules on the chest and neck and has now become blistered and eroded and involves the mouth and eyes. Her temperature is 39°C and she feels miserable
= immune complex mediated hypersensitivity -> severe erythema multiforme. Separation of the epidermis from the dermis; most authors believe toxic epidermal necrolysis (TEN) and SJS are different ends of the same spectrum of disease