Stevens-Johnson syndrome is an immunological skin conditions, often secondary to drugs or infection.
Initial presentation is usually a feverish prodromal period followed by a blistering erythematous skin condition – characterised by mucous membrane involvement
1922 – Albert Stevens and Frank Johnson first published a case report on two children with the skin condition at Bellevue hospital, New York. This report was also published later that year in the Lancet. It is unclear when the eponym Stevens-Johnson was first coined and by whom, possibly in the late 1940’s after both of their deaths
- There is overlap in the presentation with Toxic Epidermal Necrolysis and erythema multifome exsudativum majus.
- They are all on the spectrum of the same pathogenetic disease process
- Erythema exudativum multiforme (Hebra disease)
- Multiple cases of similar skin diseases had previously been described prior to the publication in 1922
- Hebra grouped the cases and gave the name erythema exsudativum multiforme in 1844
- Stevens and Johnson were the first to draw attention to the conjunctival involvement of the syndrome which was the distinguishing feature at that time
- Stevens AM, Johnson FC. A New Eruptive Fever. The Lancet. 1922;200(5183):1396
- Stevens AM, Johnson FC. A new eruptive fever associated with stomatitis and ophthalmia: report of two cases in children. Am J Dis Child. 1922;24(6):526-533.
- Bailey JH. 1931. Lesion of The Cornea and Conjunctiva in Erythema Exudativum Multifome (Hebra). Arch Ophthalmol. 1931;6(3):362-379.
- Hebra F. On diseases of the skin, including the exanthemata. 1866 [Translated text]
- Bohigian, George M. 2015. The history of Stevens-Johnson Syndrome and a case study. St. Louis: Center for History of Medicine at Washington University School of Medicine, 2015
- Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol. 1993 Jan;129(1):92-6. [PMID 8420497]
- Thomas BA. So-called Stevens—Johnson Syndrome. Br Med J. 1950 Jun 17; 1(4667): 1393–1397. [PMC2038151]
- Rzany B et al. Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990-1992): structure and results of a population-based registry. J Clin Epidemiol. 1996 Jul;49(7):769-73. [PMID 8691227]
- Mockenhaupt M. The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol. 2011 Nov;7(6):803-13; quiz 814-5. [PMID 22014021]