Stevens-Johnson syndrome is an immunological skin conditions, often secondary to drugs or infection.
Initial presentation is usually a feverish prodromal period followed by a blistering erythematous skin condition – characterised by mucous membrane involvement
- 1922 – Albert Stevens and Frank Johnson first published a case report on two children with the skin condition at Bellevue hospital, New York. This report was also published later that year in the Lancet.
- It is unclear when the eponym Stevens-Johnson was first coined and by whom, possibly in the late 1940’s after both of their deaths
- There is overlap in the presentation with Toxic Epidermal Necrolysis and erythema multifome exsudativum majus.
- They are all on the spectrum of the same pathogenetic disease process
- Erythema exudativum multiforme (Hebra disease)
- Multiple cases of similar skin diseases had previously been described prior to the publication in 1922
- Hebra grouped the cases and gave the name erythema exsudativum multiforme in 1844
- Stevens and Johnson were the first to draw attention to the conjunctival involvement of the syndrome which was the distinguishing feature at that time
- Stevens AM, Johnson FC. A New Eruptive Fever. The Lancet. 1922;200(5183):1396
- Stevens AM, Johnson FC. A new eruptive fever associated with stomatitis and ophthalmia: report of two cases in children. Am J Dis Child. 1922;24(6):526-533.
- Bailey JH. 1931. Lesion of The Cornea and Conjunctiva in Erythema Exudativum Multifome (Hebra). Arch Ophthalmol. 1931;6(3):362-379.
- Hebra F. On diseases of the skin, including the exanthemata. 1866 [Translated text]
- Bohigian, George M. 2015. The history of Stevens-Johnson Syndrome and a case study. St. Louis: Center for History of Medicine at Washington University School of Medicine, 2015
- Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol. 1993 Jan;129(1):92-6. [PMID 8420497]
- Thomas BA. So-called Stevens—Johnson Syndrome. Br Med J. 1950 Jun 17; 1(4667): 1393–1397. [PMC2038151]
- Rzany B et al. Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990-1992): structure and results of a population-based registry. J Clin Epidemiol. 1996 Jul;49(7):769-73. [PMID 8691227]
- Mockenhaupt M. The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol. 2011 Nov;7(6):803-13; quiz 814-5. [PMID 22014021]