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Tag Holmes-Adie Pupil
CCC Critical Care Compendium 680

Fixed dilated pupil DDx

Suspect herniation due to an intracranial mass lesion as a cause of fixed dilated pupil in an unconscious patient. A fixed dilated pupil in an awake patient is NOT due to herniation.
William John Adie (1886 – 1935)

William John Adie

William John Adie (1886 – 1935) was an Australian neurologist. Best known for describing the tonically dilated pupil (Adie pupil) associated with absent deep tendon reflexes (Adie syndrome) and his description of narcolepsy
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Adie syndrome

Holmes-Adie syndrome (aka Adie syndrome) affects the autonomic nervous system. Patients present with the pupil of one eye being larger and only slowly constricts in bright light (tonic pupil). There is also absence of deep tendon reflexes, usually the Achilles tendon.