William John Adie

William John Adie (1886-1935) was an Australian neurologist.

Best known for describing the tonically dilated pupil (Adie pupil) associated with absent deep tendon reflexes (Adie syndrome) and his description of narcolepsy

Biography

• Born 31 October 1886 Geelong, Australia
• 1932 – Co-founder of the Association of British Neurologists; first meeting 28 July at the house of Gordon Morgan Holmes
• Died 17 March 1935

Medical Eponyms

Adie Syndrome (1931)

Holmes-Adie syndrome (aka Adie syndrome) affects the autonomic nervous system. Patients present with the pupil of one eye being larger and only slowly constricts in bright light (tonic pupil). There is also absence of deep tendon reflexes, usually the Achilles tendon.

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Major Publications

• Adie WJ. Pseudo-Argyll Robertson pupils with absent tendon reflexes. A benign disorder simulating tabes dorsalis. Br Med J. 1931 May 30;1(3673):928-30
• Adie WJ. Argyll Robertson pupils true and false Br Med J. 1931 Jul 25;2(3681):136-8. [PMC2315730]
• Adie WJ. Tonic pupils and absent tendon reflexes: a benign disorder sui generis; its complete and incomplete forms. Brain 1932;55:98–113
• Adie WJ. Complete and incomplete forms of the benign disorder characterised by tonic pupils and absent tendon reflexes. Br J Ophthalmol. 1932 Aug; 16(8): 449–461. [PMC511452]
• Adie WJ, Critchley M. Forced grapsing and groping. Brain 1927;50:142-70.
• Adie WJ. Idiopathic narcolepsy: a disease sui generis: with remarks on the mechanism of sleep. Brain 1926;49:275–306.
• Adie WJ, Wagstaffe WW. A note on a series of 656 cases of gunshot wound of the head, with a statistical consideration of the results obtained. Medical Research Committee Statistical Reports, no. 1. London: Stationery Office, 1918

References

Biography

Eponymous terms

• Obituary: William John Adie. Br Med J. 1935 March 23;1(3872):624-5
• Obituary: William John Adie, M.D. Edin., F.R.C.P. Lond. Lancet 1935; 225:5821; 717.
• Pearce JMS. William John Adie (1886–1935). J Neurol Neurosurg Psychiatry 2004; 75: 1111
• Holmes GM. Partial iridoplegia associated with symptoms of other diseases of the nervous system. Trans ophthal Soc 1931;51:209–28.
• Brody IA, Wilkins RH. Neurology classics VII – Adie’s Syndrome. Arch Neurol. 1968;18(6):710-715.
• Siddiqui AA, Clarke JC, Grzybowski A. William John Adie: the man behind the syndrome. Clin Exp Ophthalmol. 2014 Nov;42(8):778-84. [PMID 24533698]
• Beighton G, Wiedemann HR. The Person Behind the Syndrome. Springer. 1997 pp 4-6

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