Holmes-Adie syndrome (aka Adie syndrome) affects the autonomic nervous system. Patients present with the pupil of one eye being larger and only slowly constricts in bright light (tonic pupil). There is also absence of deep tendon reflexes, usually the Achilles tendon.


1812 – James Ware described some features in his dissertation on Observations relative to the near and distant sight of different persons read November 1812, published 1813

1881 – John Hughlings Jackson described the syndrome in full [1881: 1: 139-154.]

1899 – Pilz

1902 – Julius Strasberger, Alfred Saenger and Max Nonne further described and defined the pupillary findings.

1906 – C. Markus, Transactions of the Ophthalmological Society of the United Kingdom 1906, 26, 50.

1914 – H. Oloff determined that the condition was not syphilitic in origin

1926 – Weill and Reys summarised the condition completely

1931William John Adie recognised the work of his colleagues including Foster Moore (described 15 such cases 1924-1931) who later expressed his ‘dissatisfaction’ at not having been ascribed the eponym…

1931Gordon Morgan Holmes described 19 patients with the condition

1934Jean-Alexandre Barré first used the term ‘syndrome d’Adie

Alternative names
  • Adie pupil
  • Adie-Holmes syndrome
  • Holmes-Adie syndrome
  • Weill-Reys syndrome

Associated Persons


Original articles

Review articles


the names behind the name

Dr Ege Eroglu Profile picture LITFL 2

MD (The University of Notre Dame, Australia). Doctor at Sir Charles Gairdner Hospital, Perth, Western Australia. Interested in critical care medicine, paediatrics, ENT and ophthalmology.

BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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