A 23 year-old male is brought to your ED by a friend. He appears anxious, distressed and confused. His friend volunteers that the patient had seen a GP in the past few weeks as he was feeling depressed.
Toxidrome challenge lets you test yourself on anticholinergic toxicity, malignant hyperthermia, neuroleptic malignant syndrome, and serotonin syndrome.
Serotonin syndrome results from drug-induced over-stimulation of serotonin receptors in the CNS and is characterized by a triad of CNS dysfunction, autonomic disturbance and neuromuscular effects; aka serotonin toxicity
Toxidromes associated with hyperthermia may be difficult to distinguish: serotonin syndrome; anticholingeric syndrome; sympathomimetic syndrome; neuroleptic malignant syndrome; malignant hyperthermia