Serotonin Syndrome
Serotonin syndrome results from drug-induced over-stimulation of serotonin receptors in the CNS and is characterized by a triad of CNS dysfunction, autonomic disturbance and neuromuscular effects; aka serotonin toxicity
Tag Toxidromes
Cholinergic Syndrome
Cholinergic Toxidrome
Sedative Toxidrome
Sedative toxidrome: agents - opioids; benzodiazepines; barbiturates; baclofen (may mimic brain death, suspect in MS patients); clonidine (mimics opioid toxidrome with marked bradycardia and hypotension)
GHB
Sympatholytic toxidrome
True sympatholytic agents (e.g. alpha-blockers like phentolamine, and vasodilatory agents such as GTN, SNP, etc)≥ Also beta-blocker; ca2+ blocker;
clonidine; digoxin
Toxic agents and abnormal vital signs
Abnormal vital signs in patient's following toxic exposures can suggest underlying toxidromes. Differential diagnosis of abnormal signs
Anticholinergic Syndrome
Anticholinergic Syndrome
Sympathomimetic toxidrome
Sympathomimetic toxidrome
Hyperthermia-associated toxidromes
Toxidromes associated with hyperthermia may be difficult to distinguish: serotonin syndrome; anticholingeric syndrome; sympathomimetic syndrome; neuroleptic malignant syndrome; malignant hyperthermia
Kloss and Bruce Tox in a Box
Pocket Toxicology Flashcards by Brian Kloss and Travis Bruce.\ aka Tox in a Box with examples on the Toxicology flashcards page