Serotonin syndrome results from drug-induced over-stimulation of serotonin receptors in the CNS and is characterized by a triad of CNS dysfunction, autonomic disturbance and neuromuscular effects; aka serotonin toxicity
True sympatholytic agents (e.g. alpha-blockers like phentolamine, and vasodilatory agents such as GTN, SNP, etc)≥ Also beta-blocker; ca2+ blocker;
clonidine; digoxin
Toxidromes associated with hyperthermia may be difficult to distinguish: serotonin syndrome; anticholingeric syndrome; sympathomimetic syndrome; neuroleptic malignant syndrome; malignant hyperthermia