Valproate: Still Big Trouble!
The patient from Toxicology Conundrum 055 with a massive valproate overdose arrives in the ICU, can you manage things from here?
The patient from Toxicology Conundrum 055 with a massive valproate overdose arrives in the ICU, can you manage things from here?
A man presents with decreased level of consciousness following a probable ingestion of 96g of sodium valproate. Can you handle this toxicological emergency?
Sodium valproate is a commonly used anti-epileptic drug, that come sin standard and enteric coated forms. Toxicity is characterised by metabolic failure, resulting in multi-organ dysfunction and cerebral edema