Virginia P. Sybert. is an American medical geneticist and dermatologist.
She is currently working as professor of Medicine and Medical Genetics at University of Washington and is also a board certified physician at the Genetic Medicine Clinic and the Center on Human Development and Disability at University of Washington Medical Center, specialising in medical genetics, dermatology and pediatrics.
Her area of expertise is in inherited disorders of the skin and Turner syndrome.
In 1988 Sybert et al published a paper describing a hereditary palmar-plantar keratoderma distinct from those previously identified, which has since been recognised by the eponymous name palmoplantar keratoderma of Sybert.
- 1974 – MD, State University of New York at Buffalo, School of Medicine
- Residency and internship in paediatrics at University of California, San Francisco
- 1982 – certified with the American Board of Medical Genetics
- 1979 – certified with the American Board of Pediatrics
- Fellowship in dermatology at Univeristy of Washington
- Fellowship in paediatrics at Children’s Hospital and Regional Medical Center, Seattle
- 2014 awarded Castle Connolly Regional Top Doctor
- Clinical Professor in Medical Genetics at the University of Washington
- On the editorial board for Paediatric Dermatology
- Author of Genetic Skin Disorders
Palmoplantar keratoderma (PPK) of Sybert (1988)
The hereditary palmar-plantar keratodermas are a heterogeneous group of disorders characterized by hyperkeratosis of the palms and soles and distinguishable by other clinical characteristics, associated abnormalities, and mode of inheritance. We report a family with a new autosomal dominant condition with clinical similarities to mal de Meleda and Greither’s disease.
…34-year-old white man first seen with a lifelong history of erythema and scaling of the palms and soles…With age the elbows, knees, backs of the hands, posterior aspects of the forearms, tops of the feet, and anterior aspects of the legs became involved. The hyperkeratosis was so severe that spontaneous amputations and deformities of the digits had occurredSybert 1988
The nosology of the palmoplantar keratodermas is complex; disorders have been distinguished by mode of inheritance, sites of involvement, and associated abnormalities. PKK of Sybert is an autosomal dominant inherited PKK characterised by severe erythema, hyperkeratosis, and desquamation with bilateral involvement of the palms and soles with a tendency for lateral and dorsal extension and can result in autoamputation, but there are no systemic features. It is most similar to Greither disease, but is distinguishable clinically and by ultrasound.
PPK of Sybert is differentiated from:
- Unna-Thost disease: Autosomal dominant condition with variable involvement of the palms and soles. Typically, the lesions are thick, horny, hard, yellowish plaques with waxy smooth surfaces. Has been associated with corneal opacities, sensorineural hearing loss, and hypohidrosis. [Described by Arthur Thost (1854-1937) in 1880 and Paul Gerson Unna (1850-1929) in 1883]
- Greither disease (keratosis extremitatum hereditaria progrediens): Autosomal dominant condition with diffuse rather than focal palmoplantar keratoderma with hyperkeratotic plaques on the elbows and knees. Marked hyperhidrosis with minimal other clinical findings. Differentiated by its ‘transgrediens nature, that is, involvement of the extensor surfaces of the hands and feet. [Described in 1952 by Aloys Greither (1914-1986)]
- Vohwinkel syndrome (keratoma hereditaria mutilans) Autosomal dominant disease characterized by diffuse, honeycomb-patterned palmoplantar keratoderma, with constrictions on the fingers and toes leading to autoamputation; and mild to moderate congenital sensorineural hearing loss Vohwinkel syndrome is a diffuse palmoplantar keratoderma associated with sensorineural deafness [Described in 1929 by Dr KH Vohwinkel]
- Howel–Evans syndrome: Autosomal dominant condition with hyperkeratosis of the skin of the palms of the hands and the soles of the feet. High lifetime risk of oesophageal cancer. Sometimes termed tylosis with oesophageal cancer; Palmoplantar ectodermal dysplasia type III; or tylosis palmaris et plantaris [First described in 1958 by William Howel-Evans (1891–1939)]
- Mal de Meleda: Autosomal recessive disease that is defined by a diffuse, transgressive palmoplantar erythrokeratoderma with hyperhidrosis and nail changes. Hyperkeratosis of the elbows and knees and perioral erythema may also be present. [Meleda; Italian name for the Croatian island of Mljet where the first observations were made. [First description in 1934 by Franjo Kogoj (1894–1983)]
- Sybert VP, Dale BA, Holbrook KA. Palmar-plantar keratoderma. A clinical, ultrastructural, and biochemical study. J Am Acad Dermatol. 1988;18(1 Pt 1):75-86.
- Sybert VP. Genetic skin disorders. 2e. Oxford University Press. 2010
- Sybert VP. Genetic skin disorders. 3e. Oxford University Press. 2017
- Sybert VP, Francis JS, Corden LD, et al. Cyclic ichthyosis with epidermolytic hyperkeratosis: A phenotype conferred by mutations in the 2B domain of keratin K1. Am J Hum Genet. 1999;64(3):732-738
- Sybert VP, McCauley E. Turner’s syndrome. N Engl J Med. 2004;351(12):1227-1238.
- Bader E, Shipman AR. The women behind the names: Dermatology eponyms named after women. Int J Womens Dermatol. 2017;3(1 Suppl):S38-S41
- Bibliography. Sybert, Virginia P.. WorldCat Identities
- Bio. Virginia P. Sybert M.D., UW Medicine website
- Thost A. Über erbliche Ichtyosis palmaris et plantaris cornea. Dissertation, Heidelberg, 1880.
- Unna PG. Über das Keratoma palmare et plantare hereditarium. Vierteljahrsschrift für Dermatologie und Syphilis, 1883; 15: 231-270
- Vohwinkel KH. Keratoma hereditarium mutilans. Archiv für Dermatologie und Syphilis. 1929; 158(2): 354–364
- Kogoj F. Die Krankheit von Mljet (“Mal de Meleda”). Acta Dermato-Venereologica. 1934; 15: 264–299.
- Greither A. Keratosis extremitatum hereditaria progrediens mit dominantem Erbgang. Hautarzt. 1952;3:198-203.
- Howel-Evans W, McConnell RB, Clarke CA, Sheppard PM. Carcinoma of the oesophagus with keratosis palmaris et plantaris (tylosis): a study of two families. Q J Med. 1958;27(107):413-429.
- Greither A, Tritsch H. Über einen Fall von anhidrotischer ektodermaler Dysplasie mit nahezu vollständiger Alopecie, transgredienten Palmar-Plantar-Keratosen, Macula-Degeneration sowie anderen Augenstörungen, Zahnanomalien und einem Pseudo-Klinefelter-Syndrom. Arch. klin. exp. Derm. 1963; 216: 50–62.
- Kansky A, Arzensek J. Is palmoplantar keratoderma of Greither’s type a separate nosologic entity.’? Dermatologica 1979; 158:244-8.
- Tanew A, Diridl E, Breier F, Itin PH, Rappersberger K, Hönigsmann H. Hereditary, focal, transgressive palmoplantar keratoderma with associated clinical findings: a new entity?. Br J Dermatol. 2002;146(3):490-494.
- Tiwary A, Mishra D. Transgrediens et progrediens palmoplantar keratoderma of Sybert: Four cases in a single family. Iran J Dermatol 2016; 19: 60-64.
the person behind the name