Whipple procedure


Whipple procedure: Radical pancreatoduodenectomy for cancer of pancreas. Excision of the head of the pancreas, the gallbladder, part of the common bile duct, the duodenum, and sometimes a portion of the stomach, with gastrojejunostomy, choledochojejunostomy, and pancreaticojejunostomy.


1898 – Italian surgeon Alessandro Codivilla (1861-1912) performed the first reported pancreaticoduodenectomy for carcinoma of the pancreas. He removed parts of the pancreas, duodenum, distal stomach and distal bile duct and performed Roux-en-Y gastrojejunostomy and cholecystojejunostomy. The pancreatic stump was not closed. The patient died on day 18.

1909 – Walther Kausch performed the first successful partial pancreatoduodenectomy (excision of the duodenum and a portion of the pancreas in two stages), for ampullary cancer. Published in 1912

1934 – Whipple

Associated Persons
Alternative names
  • Pancreaticoduodenectomy, pancreatoduodenectomy
  • Kausch-Whipple operation

Historical references

  • Codivilla A. Contributo alla chirurgia gastrica [Contribution to gastric surgery]. Rendiconti statistici della Sezione Chirurgica dell’Ospedale di Imola. 1898.
  • Kausch W. Das Carcinom der Papilla duodeni und seine radikale Entfernung. Beiträge zur klinischen Chirurgie. 1912; 78: 439-486.
  • Whipple AO. Parsons WB, Mullins CR. Treatment of carcinoma of the ampulla of Vater. Annals of Surgery. 1935;102(4): 763-779.

Reviews references

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medical etymology

BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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