Month January 2019
CCC Critical Care compendium 340

Genetics and Critical Illness

There is increasing awareness of genetic make up influencing one’s ability to respond in critical illness. It is believed that genetic predisposition influences the risk of serious infection and outcome.

CCC Critical Care compendium 340

Hiccoughs

Hiccoughs or hiccups refer to frequent involuntary intermittent contraction of the diaphragm, often occurring several times a minute

CCC Critical Care compendium 340

Anti-NMDA Receptor Encephalitis

Anti-NMDA Receptor Encephalitis is an under-recognised progressive neurological disorder caused by antibodies against NR1-NR2 NMDA receptors; 60% of patients with anti-NMDA receptor encephalitis have the presence of a tumour (most commonly teratoma)

CCC Critical Care compendium 340

Basilar Artery Occlusion

Basilar Artery Occlusion: the clinical effects will be dependent on: adequacy of collaterals, integrity of the Circle of Willis and the onset of the occlusion; occlusion at the bifurcation will involve the posterior cerebral artery +/- the superior cerebellar artery

CCC Critical Care compendium 340

Celecoxib

Celecoxib: COX II inhibitor; blocks access of arachidonic acid to active site at apex of a hydrophobic channel on COX-2

CCC Critical Care compendium 340

Botulism

Botulism: endotoxins from Clostridium botulinum (and other Clostridia) -> prevents the release of Ach -> neuroparalytic disorder; spore forming anaerobes with heat resistant spores found in soil and marine sediment