Month March 2019
Toxicology-Library-Toxicant-Drug-340-256

Metformin toxicity

Metformin rarely causes hypoglycaemia but it can cause a profound lactic acidosis in overdose and in patients with renal failure.

Toxicology-Library-Toxicant-Drug-340-256

Insulin toxicity

While insulin overdose should be simple to manage this guide will show you some of the nuances to the management and help you prevent longterm neurological impairment.

Toxicology-Library-Toxicant-Drug-340-256

Tramadol toxicity

Tramadol in overdose would have the opiate toxidrome expected (sedation and respiratory depression) but it also can potentially cause seizures in doses >1.5 grams. Tramadol has also been associated with serotonin toxicity, rarely as a single agent but commonly with other co-ingested serotinergically active agents.

Toxicology-Library-Toxicant-Drug-340-256

Salicylate toxicity

Salicylates in acute overdose classically cause a respiratory alkalosis by stimulating the respiratory centres in the brain followed by a metabolic acidosis by uncoupling oxidative phosphorylation. The classic triad of mild toxicity is nausea, vomiting and tinnitus,

CICM Exam Library 340

CICM SAQ 2011.2 Q13

You are asked to admit a 46-year-old man who has just been intubated in the Emergency Department after collapsing from what appears clinically to be a brain stem stroke. His Glasgow Coma Score prior to intubation was 6.

UCEM-logo 340

A Fondness of Fruit

Most of us, at one time or another, have gazed into the stratosphere and imagined clouds as familiar objects such as an animal, a face, an activity or letter of the alphabet. Such nephelococcygial activity has never resulted in my…

Toxicology-Library-Toxicant-Drug-340-256

Local Anaesthetic

Local Anaesthetic toxicity is nearly always due to a therapeutic error. Usually an incorrect dose, route or technique.

Toxicology-Library-Toxicant-Drug-340-256

Chloral Hydrate

Chloral hydrate is used in paediatrics undergoing procedures. It was withdrawn from the adult arena due to the narrow therapeutic index. In overdue it causes rapid CNS depression, cardiac dysrhythmias and these are lethal without prompt intervention.Chloral hydrate comes in 200ml bottles, 1g/10ml

Toxicology-Library-Tox-library-LITFL 340

12-lead ECG in Toxicology

The 12-lead ECG provides valuable real-time prognostic information that is based on toxic effects at the target organ; often not available from clinical evaluation or serum drug assays.