Neurological Toxicity of Chemotherapy
OVERVIEW
- Encephalopathy
- Cerebellar Syndrome
- Myelopathy
- Peripheral Neuropathy
- Stroke and Venous Thrombosis
- SIADH
- Cranial Nerve Involvement
- Aseptic meningitis
- Leucoencephalitis
- Ocular toxicity
CAUSES
Encephalopathies
- BiCNU
- cisplatin
- cytarabine
- 5-FU
- ifosfamide
- asparaginase
- methotrexate
- procarbazine
Cerebellar Syndrome
- cytarabine
- 5-FU
Myelopathy
- intrathecal methrotrexate
- cytarabine
- thiotepa
Peripheral Neuropathy
- vincristine
- cisplatin
- taxanes
Stroke and Cerebral Vein Thrombosis
- asparaginase
- high dose methotrexate
- BiCNU
- cisplatin by intracarotid injection
Ototoxicity
- cisplatin
SIADH
- vincristine
Cranial Nerve Involvement
- vincristine
- ifosfamide
Aseptic Meningitis
- intrathecal methotrexate
- cytrarabine
Leucoencephalitis
- methotrexate
Ocular toxicity
- cisplatin
- vincristine
Critical Care
Compendium
Chris is an Intensivist and ECMO specialist at The Alfred ICU, where he is Deputy Director (Education). He is a Clinical Adjunct Associate Professor at Monash University, the Lead for the Clinician Educator Incubator programme, and a CICM First Part Examiner.
He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives. He was one of the founders of the FOAM movement (Free Open-Access Medical education) has been recognised for his contributions to education with awards from ANZICS, ANZAHPE, and ACEM.
His one great achievement is being the father of three amazing children.
On Bluesky, he is @precordialthump.bsky.social and on the site that Elon has screwed up, he is @precordialthump.
| INTENSIVE | RAGE | Resuscitology | SMACC