Adolphe-Marie Gubler
Adolphe-Marie Gubler (1821-1879) was a French physician and therapeutic pharmacologist.
Gubler published extensively in various areas of medicine, including neurology, where he studied conditions such as migraine, neurological damage during acute rheumatic fever, aphasia, and the autonomic nervous system.
Gubler contributed to the study of vascular accidents affecting the brain stem, which led to the eponymous Millard-Gubler syndrome (1856), a condition characterized by crossed hemiplegia and named after him and Auguste Millard (1830-1915)
Gubler is also known for differentiating between haematogenous and hepatogenous icterus.
Biography
- Born on April 5, 1821
- 1845 – Interne
- 1849 – Doctorate in Paris
- 1865 – Member of Académie de médecine
- 1868 – Professor of therapeutics, Paris
- Died April 20, 1879
Medical Eponyms
Millard-Gubler syndrome (1856)
[*aka Gubler paralysis, Gubler syndrome] A pontine lesion affecting the seventh cranial nerve nucleus and the descending pyramidal fibres on one side of the ventral pons, causing homolateral facial paresis and contralateral hemiplegia.
1855 – Auguste Millard (1830-1915) in a brief publication, first proposed to the Société anatomique de Paris that direct facial hemiplegia accompanied by contralateral hemiplegia was a sign of pontine haemorrhage. “L’hémiplégie du mouvement du côté opposé à répanchement et l’hémiplégie faciale directe.”
1856 – Millard provided further description of two patients with ipsilateral facial hemiplegia accompanied by contralateral hemiplegia and pontine haemorrhage. Firstly a patient of Poisson’s and secondly a case reported by Sénac of a fruit and vegetable merchant whose autopsy revealed a 5mm midpontine area of bluish-black softening that contained an “almond-sized” haemorrhagic center.
1856 – Adolphe Gubler (1821-1897) described six additional cases and reviewed pontine neuroanatomy, including purported evidence for decussation of the facial motor fibres. Gubler’s first patient was a woman with pulmonary TB, a right hemiparesis, and left facial weakness. Autopsy revealed a firm mass about the size of “a husked filbert” (12 to 15 mm in diameter) that invaded both sides of the pons but destroyed more of the left side. The seventh-nerve fibres emerging from the pons were “little if at all impaired.”
His other cases were similar, including one first reported by Grenet of a 34-year-old man with left facial paralysis and anaesthesia associated with right hemiparesis and hemianaesthesia.
In an addendum to Gubler’s article, Millard requested that his two cases be reprinted, for he agreed with Gubler that “crossed facial hemiplegia” was a sign of pontine lesions. An attached editor’s note indicated that Gubler had acknowledged Millard as the first to recognize a possible relationship between “direct facial hemiplegia” and pontine lesions. This admission and Millard’s correspondence explain the attachment of Millard’s name to Gubler’s.
1893 – Jean-Martin Charcot (1825-1893) referred to “la paralysie alterne de Gubler” but also acknowledged Millard’s discovery occurring around the same time and justified the use of both names in the eponym.the eponymic use of both names.
Other eponyms
- Gubler line
- Gubler tumor (1868)
Major Publications
- Gubler A-M. Desglandes de Méry (Cooper) et de leurs maladies chez l’homme, Thèse de doctorat, Paris, 1849
- Gubler A-M. De l’hémiplégie alterne envisagée comme signe de lésion de la protubérance annulaire et comme preuve de la décussation des nerfs faciaux. Gazette hebdomadaire de médecine et de chirurgie. 1856; 3: 749-754, 789-792, 811-816. [Millard-Gubler syndrome]
- Gubler A-M. De la tumeur dorsale des mains dans la paralysie saturnine des extenseurs des doigts. L’Union médicale. 1868; 6: 2-8, 15-19, 26-30. [Gubler tumor]
- Gubler A-M. Commentaires thérapeutiques du Codex medicamentarius. 1868
- Gubler A-M. The principles and methods of therapeutics. 1881
References
Biography
- Fresquet JL. Adolphe-Marie Gubler. Historia de la Medicina
- Walusinski O. Adolphe Gubler (1821-1879) or Parisian neurology outside La Salpêtrière in the age of Jean-Martin Charcot. Rev Neurol (Paris). 2019 Apr;175(4):207-216.
Eponymous terms
- Millard A. Extrait du Rapport. Bulletins de la Société anatomique de Paris. 1855; 30: 206-207
- Millard A. Extrait du rapport de M. Millard sur les observations précédentes. Bulletins de la Société anatomique de Paris. 1856; 31: 217-221.
- Millard A. A monsieur le redacteur en chef de la Gazette Hebdomadaire. Gazette hebdomadaire de médecine et de chirurgie. 1856; 3: 816-818.
- Charcot J-M. Le syndrome de Benedikt. Médecine moderne, 1e mars 1893, p. 194.
- Silverman IE, Liu GT, Volpe NJ, Galetta SL. The crossed paralyses. The original brain-stem syndromes of Millard-Gubler, Foville, Weber, and Raymond-Cestan. Arch Neurol. 1995 Jun;52(6):635-8.
Eponym
the person behind the name
Physician in training. German translator and lover of medical history.
