The Cabot-Locke murmur is an early diastolic murmur found in patients with severe anaemia. The murmur resolves with treatment of the anaemia. There is no functional valvular abnormality present.
Unlike the early diastolic murmur associated with aortic regurgitation, the Cabot-Locke murmur has no associated ‘decrescendo’ phase.
Note: The description of the Cabot-Locke murmur was based on a study sample of three patients…
- Cabot RC, Locke EA. On the occurrence of diastolic murmurs without lesions of the aortic or pulmonary valves. Bull Johns Hopkins Hosp 1903;14:115-20.
- Ma I, Tierney LM. Name that murmur–eponyms for the astute auscultician. N Engl J Med. 2010 Nov 25;363(22):2164-8.[PMID 21105801]