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Description

The Cabot-Locke murmur is an early diastolic murmur found in patients with severe anaemia. Unlike the early diastolic murmur associated with aortic regurgitation, the Cabot-Locke murmur has no associated ‘decrescendo’ phase.

The murmur resolves with treatment of the anaemia. There is no functional valvular abnormality present.

Note: The description of the Cabot-Locke murmur was based on a study sample of three patients

In cases of intense anaemia, when the red cells are reduced to or below 1,000,000 per cu. mm, one occasionally hears diastolic murmurs not to be explained by permanent dilatation of the aortic ring nor as “cardio-respiratory murmurs”, and not due to a diastolic accentuation of a venous hum. The cause of these murmurs is obscure

Cabot R, Locke E. 1903: 120

Associated Persons

References

Original articles

Review articles


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U.K trained doctor currently working in ED in Perth my interests include all things acute medicine.

BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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