Edwin Allen Locke

Edwin Allen Locke (1874-1971) was an American Physician

Much of his work and interests within medicine involved care and treatment of tuberculosis and pulmonary disease.

Collaborated with Richard Clarke-Cabot and noted an early diastolic murmur, heard in untreated anaemia, with normal valvular anatomy. The murmur sounds similar to aortic regurgitation, but without a decrescendo and resolves with the treatment of anaemia – the Cabot-Locke murmur (1903).

  • Born on October 15, 1874 Halifax, Massachusetts.
  • 1896 – Bachelor of Philosophy, Brown University.
  • 1897 – Master of Arts, Brown University.
  • 1901 – Graduated from Harvard Medical School.
  • 1902 – Appointed ‘House Pupil’ at Massachusetts General Hospital. Awarded Dalton Scholarship to investigate ‘Osteitis deformans and allied affections‘.
  • 1903 – Started work at Boston City Hospital as Physician to Outpatients.
  • 1905 – Founding member of the Interurban Clinical Club
  • 1918 – set up a special ward for the treatment of patients during the influenza pandemic at Boston City Hospital.
  • 1921 – Part of the first organised group practice in Boston.
  • 1923 – Clinical Professor of Medicine, Harvard.
  • 1934 – President of the Harvard Medical School Alumni Association.
  • 1935 – Resigned from clinical duties to become Professor of Hygiene and Director of Health and Athletics at Williams College.
  • 1942 – Retired and subsequently cared for his wife who suffered a severe stroke.
  • Died on March 6, 1971 aged 96

Medical Eponyms
Cabot-Locke murmur (1903)

The Cabot-Locke murmur is an early diastolic murmur found in patients with severe anaemia. The murmur resolves with treatment of the anaemia. There is no functional valvular abnormality present. Unlike the early diastolic murmur associated with aortic regurgitation, the Cabot-Locke murmur has no associated ‘decrescendo’ phase.

Note: The description of the Cabot-Locke murmur was based on a study sample of three patients…

In cases of intense anaemia, when the red cells are reduced to or below 1,000,000 per cu. mm, one occasionally hears diastolic murmurs not to be explained by permanent dilatation of the aortic ring nor as “cardio-respiratory murmurs”, and not due to a diastolic accentuation of a venous hum. The cause of these murmurs is obscure

Cabot R, Locke E. 1903: 120

Major Publications



Eponymous terms


BA MA (Oxon) MBChB (Edin) FACEM FFSEM. Emergency physician, Sir Charles Gairdner Hospital.  Passion for rugby; medical history; medical education; and asynchronous learning #FOAMed evangelist. Co-founder and CTO of Life in the Fast lane | Eponyms | Books | Twitter |

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