Category Acid-base
CCC Critical Care compendium 340

Metabolic Acidosis Evaluation

A metabolic acidosis is a process which, if uncorrected, would lead to an acidaemia. It is usually associated with a low bicarbonate concentration (or total CO2), but an acidosis may be masked by a co-existing metabolic alkalosis.
CCC Critical Care compendium 340

Lactic Acidosis Evaluation

increased lactate production (including enhanced pyruvate production, reduced pyruvate conversion to CO2 & water or glucose, or preferential conversion of pyruvate to lactate)
CCC Critical Care compendium 340

Ketoacidosis

Ketoacidosis is a high anion gap metabolic acidosis due to an excessive blood concentration of ketone bodies (keto-anions).
CCC Critical Care compendium 340

Delta Ratio

Delta Ratio = the increase in Anion Gap / the decrease in HCO3-. if one molecule of metabolic acid (HA) is added to the ECF and dissociates, the one H+ released will react with one molecule of HCO3- to produce CO2 and H2O (buffering).
CCC Critical Care compendium 340

Base Excess vs Standard Base Excess

Base excess is dose of acid or alkali to return in vitro blood to normal pH (7.40) under standard conditions ( at 37C at a PCO2 of 40 mm Hg). Standard base excess is dose of acid or alkali to return the ECF to normal pH (7.40) under standard conditions ( at 37C at a PCO2 of 40 mm Hg)
CCC Critical Care compendium 340

Strong Ion Difference

Strong Ion Difference - The quantitative approach to acid-base chemistry is also known as the physicochemical method or the Stewart approach
CCC Critical Care compendium 340

Pyroglutamic Acidosis

Pyroglutamic acidosis is a rare cause of high anion gap metabolic acidosis (HAGMA). When glutathione levels are low, the activity of γ-glutamyl cyclotransferase is increased, resulting in pyroglutamic acid accumulation in glutathione-depleted states
CCC Critical Care compendium 340

D-Lactic acidosis

D-Lactic acidosis aka D-lactic encephalopathy. Rare cause of high anion gap metabolic acidosis (HAGMA), typically occurs in patients short bowel syndrome or following jejuno-ileal bypass surgery