SIADH
Syndrome Of Inappropriate ADH secretion (SIADH) is hyponatraemia due to an increase in concentration of ADH inappropriate to the current osmotic or volume status. The differential diagnosis includes ADH analogues
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Hyponatraemia
Hyponatraemia: common problem in ICU (30% of patients have a Na < 134mmol/L). Independent predictor of mortality in ICU
Hypophosphataemia
Hypophosphataemia: Phosphate - important intracellular anion; 85% is stored in bone as hydroxyapapitie crystals, 14% in soft tissues, 1% in blood
Hypokalaemia
Hypokalaemia: the most common electrolyte abnormality in hospitalised patients; mostly caused by drugs and GI disease
Hypocalcaemia
Hypocalcaemia: Reduced intake; redistribution and increased output
Hypernatraemia
Hypernatraemia can be caused by a number of critical illnesses: water depletion (decreased intake, hypotonic fluid loss – renal/non-renal); solute excess (Na+ or other)
Hyperkalaemia Management
Hyperkalaemia is a life-threatening emergency. Basic overview of hyperkalemia management
Hypercalcaemia
Ca2+ exists in the extracellular plasma two states: (1) free ionized state and (2) bound to other molecules (mostly albumin, rest – beta-globulins, phosphate, citrate)
ionized Ca2+ concentration is inversely related to pH -> an increase in pH results in a decrease in ionized Ca2+
Clostridium difficile and PMC
Pseudomembranous colitis (PMC); acute inflammatory disease of colon commonly associated with antibiotic use; C. difficile implicated as a causative organism in 1970’s
Portopulmonary syndrome
Portopulmonary Syndrome is NOT considered contraindication to liver transplantation; affects ~20% of pre-transplant patients; usually due to increased blood flow through the lungs without increased resistance
Cuff Pressure Gauge
Cuff pressure gauge aka cuff manometer; allows safe inflation of the cuff seal of low pressure endotracheal and laryngeal tube cuffs by measuring the cuff pressure
Transplant Patient Hot Case
GENERAL APPROACH Considerations Transplant – liver, heart, lung, heart-lung, bone marrow, renal, pancreatic Phase of care – immediate post op, sepsis, rejection, respiratory failure, renal failure Surgery – graft function, anatomy, anastomoses (leaks and occlusion) Infection – bacterial (early), opportunistic:…