Intra-arrest therapeutic hypothermia
Therapeutic hypothermia (T33°C) after return of spontaneous circulation (ROSC) was not found to confer benefit compared to normothermia (T36°C) in the TTM trial
Category CCC
The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.
Passive Leg Raise
Passive Leg Raise (PLR) transiently increases venous return in patients who are preload responsive, as such it is a diagnostic test not a treatment. It is a predictor of Fluid responsiveness
Summary of RRT Types
References and Links CCC – RRT Indications CCC – RRT principles in fluid management CCC – RRT Types CCC – RRT terminology and nomenclature CCC – RRT troubleshooting CCC – Renal Literature Summaries DerangedPhysiology.com CVVH: Continous Veno-Venous Hemofiltration circuit diagram…
Renal replacement therapy: Terminology
Renal Replacement Therapy (RRT) Terminology and Nomenclature
Gastric lavage
Gastric lavage is a GI decontamination technique that aims to empty the stomach of toxic substances by the sequential administration and aspiration of small volumes of fluid via an orogastric tube. Previously widely favoured method that has now been all but abandoned due to lack of evidence of efficacy and risk of complications.
Organophosphate Poisoning
Organophosphate Poisoning: common cause of poisoning in the developing world; covalent bonding with inactivation of acetylcholinesterase; results in cholinergic crisis
Polonium
the radioactive isotope polonium-210 was implicated in the death of former KGB/ FSB operative Alexander Litvenko;
also has potential for use in nuclear terrorism as a 'dirty bomb'
Transfusion Literature Summaries
Transfusion Literature Summaries
AXR Interpretation
Indications for plain AXR differ depending on the availability of CT or USS, which give considerably more information. Abdominal X-rays are only useful for certain defined pathology such as abnormal ‘gases, masses, bones and stones’.
Vasopressin
Vasopressin: bioactive neuroendocrine nonapeptide; endogenously produced by the magnocellular neurone cell bodies of the paraventricular and supraoptic nuclei of the posterior hypothalamus
Direct Oral Anticoagulants (DOACs)
New oral anticoagulants (NOACs) are recently introduced medications that provide anticoagulation via the oral route by inhibiting specific clotting factors
Hypermagnesaemia
Hypermagnesaemia: Serum Mg above normal range of 1.3-2.2 mEq/L; Rare and usually iatrogenic; ↑Magnesium is closely associated with ↑K and ↓Ca