CCC

The LITFL Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care.

CCC Critical Care compendium 340

Octreotide

Octreotide: somatostatin analogue; reduces portal hypertension; antidote to sulfonylureas; reduces GI secretions

CCC Critical Care compendium 340

Omeprazole

Omeprazole: proton pump inhibitor; inhibits Na-H+ exchanger in parietal cell membrane

CCC Critical Care compendium 340

Opioids

An opioid is any psychoactive chemical that resembles opiates in their pharmacological effects by binding opioid receptors. They may be endogenous or exogenous compounds, and may be naturally occurring or synthetic

CCC Critical Care compendium 340

Paracetamol

Paracetamol (acetaminophen): simple analgesic and antipyretic - not an NSAID as it lacks significant anti-inflammatory effects

CCC Critical Care compendium 340

Physostigmine

Physostigmine: anticholinesterase; inhibition of anticholinesterase -> increase in cholinergic tone

CCC Critical Care compendium 340

Genetics and Critical Illness

There is increasing awareness of genetic make up influencing one’s ability to respond in critical illness. It is believed that genetic predisposition influences the risk of serious infection and outcome.

CCC Critical Care compendium 340

Quorum sensing

Quorum sensing is the capacity of micro-organisms to detect extracellular, small-molecule signals and to alter gene expression in response to microbial population densities

CCC Critical Care compendium 340

Hiccoughs

Hiccoughs or hiccups refer to frequent involuntary intermittent contraction of the diaphragm, often occurring several times a minute