Category Toxicology
CCC Critical Care compendium 340

Malignant Hyperthermia CCC

Malignant Hyperthermia = pharmacogenetic disease of skeletal muscle induced by exposure to certain anaesthetic agents; incidence 1:5,000 -> 1:65,000 anaesthetics (suspected); mutation in the gene coding for the ryanodine receptor
CCC Critical Care compendium 340

Evidence-based Toxicology

Much of what we do in toxicology is because we think it works, not because we know it works. Clinical toxicology has traditionally been based on animal studies, case reports and case series based on clinical observation rather than clinical trials
CCC Critical Care compendium 340

Iron Overdose

Iron overdose can have local gastrointestinal effects as well as characteristic systemic toxicity (metabolic acidosis, liver failure, shock and multi-organ failure). Risk assessment is based on the amount of elemental iron ingested
CCC Critical Care compendium 340

Plant Toxicity

Severe toxicity from plants is rare in humans; risk assessment is often difficult - plant identification may be difficult; - toxin quantification may be impossible
CCC Critical Care compendium 340

Lithium Toxicity CCC

Lithium: acute overdose is usually benign if adequate hydration is maintained and renal function is normal; chronic toxicity can be difficult to manage and result in devastating neurotoxicity
CCC Critical Care compendium 340

Hyperthermia-associated toxidromes

Toxidromes associated with hyperthermia may be difficult to distinguish: serotonin syndrome; anticholingeric syndrome; sympathomimetic syndrome; neuroleptic malignant syndrome; malignant hyperthermia

Meow-Meow Mephedrone

Mephedrone is a new stimulant drug being abused on the street, and has recently been discovered in Australia. The following review provides emergency clinicians with assessing managing patients under the influence of mephedrone.

I’m Just Trying To Get Clean Bro’

Muttered shadows pervade the lugubrious intermission chamber with a festive rainbow of illicit degustations. Red tablets, green pills, yellow capsules, white poppers, purple hum-dingers and now…pure bath salts.